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Pharmacokinetics, pharmacodynamics and safety of aptamers.
Kovacevic KD, Gilbert JC, Jilma B. Kovacevic KD, et al. Adv Drug Deliv Rev. 2018 Sep;134:36-50. doi: 10.1016/j.addr.2018.10.008. Epub 2018 Oct 12. Adv Drug Deliv Rev. 2018. PMID: 30321620 Free article. Review.
The von Willebrand factor A-1 domain binding aptamer BT200 elevates plasma levels of von Willebrand factor and factor VIII: a first-in-human trial.
Kovacevic KD, Grafeneder J, Schörgenhofer C, Gelbenegger G, Gager G, Firbas C, Quehenberger P, Jilma-Stohlawetz P, Bileck A, Zhu S, Gilbert JC, Beliveau M, Jilma B, Derhaschnig U. Kovacevic KD, et al. Haematologica. 2022 Sep 1;107(9):2121-2132. doi: 10.3324/haematol.2021.279948. Haematologica. 2022. PMID: 34818873 Free PMC article. Clinical Trial.
The von Willebrand factor-binding aptamer rondaptivon pegol as a treatment for severe and nonsevere hemophilia A.
Ay C, Kovacevic KD, Kraemmer D, Schoergenhofer C, Gelbenegger G, Firbas C, Quehenberger P, Jilma-Stohlawetz P, Gilbert JC, Zhu S, Beliveau M, Koenig F, Iorio A, Jilma B, Derhaschnig U, Pabinger I. Ay C, et al. Among authors: kovacevic kd. Blood. 2023 Mar 9;141(10):1147-1158. doi: 10.1182/blood.2022016571. Blood. 2023. PMID: 36108308 Free PMC article.
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