Gα13-mediated LATS1 down-regulation contributes to epithelial-mesenchymal transition in ovarian cancer.
Yagi H, Onoyama I, Asanoma K, Hori E, Yasunaga M, Kodama K, Kijima M, Ohgami T, Kaneki E, Okugawa K, Yahata H, Kato K.
Yagi H, et al. Among authors: yahata h.
FASEB J. 2019 Dec;33(12):13683-13694. doi: 10.1096/fj.201901278R. Epub 2019 Sep 28.
FASEB J. 2019.
PMID: 31569999
Our findings uncover novel mechanisms through which Galpha(13) activation induces dysregulation of the Hippo signaling pathway, which leads to aggressive cancer phenotypes, and thereby identify a potential target for preventing the metastatic spread of OvCa.-Yagi, H., Onoy …
Our findings uncover novel mechanisms through which Galpha(13) activation induces dysregulation of the Hippo signaling pathway, which leads …