Izumi S - Search Results

1

A Human Immortalized Cell-Based Blood-Brain Barrier Triculture Model: Development and Characterization as a Promising Tool for Drug-Brain Permeability Studies.

Ito R, Umehara K, Suzuki S, Kitamura K, Nunoya KI, Yamaura Y, Imawaka H, Izumi S, Wakayama N, Komori T, Anzai N, Akita H, Furihata T. Ito R, et al. Among authors: izumi s. Mol Pharm. 2019 Nov 4;16(11):4461-4471. doi: 10.1021/acs.molpharmaceut.9b00519. Epub 2019 Oct 15. Mol Pharm. 2019. PMID: 31573814

2

Substrate-dependent inhibition of organic anion transporting polypeptide 1B1: comparative analysis with prototypical probe substrates estradiol-17β-glucuronide, estrone-3-sulfate, and sulfobromophthalein.

Izumi S, Nozaki Y, Komori T, Maeda K, Takenaka O, Kusano K, Yoshimura T, Kusuhara H, Sugiyama Y. Izumi S, et al. Drug Metab Dispos. 2013 Oct;41(10):1859-66. doi: 10.1124/dmd.113.052290. Epub 2013 Aug 6. Drug Metab Dispos. 2013. PMID: 23920221

3

Investigation of the impact of substrate selection on in vitro organic anion transporting polypeptide 1B1 inhibition profiles for the prediction of drug-drug interactions.

Izumi S, Nozaki Y, Maeda K, Komori T, Takenaka O, Kusuhara H, Sugiyama Y. Izumi S, et al. Drug Metab Dispos. 2015 Feb;43(2):235-47. doi: 10.1124/dmd.114.059105. Epub 2014 Nov 20. Drug Metab Dispos. 2015. PMID: 25414411

4

Investigation of Fluorescein Derivatives as Substrates of Organic Anion Transporting Polypeptide (OATP) 1B1 To Develop Sensitive Fluorescence-Based OATP1B1 Inhibition Assays.

Izumi S, Nozaki Y, Komori T, Takenaka O, Maeda K, Kusuhara H, Sugiyama Y. Izumi S, et al. Mol Pharm. 2016 Feb 1;13(2):438-48. doi: 10.1021/acs.molpharmaceut.5b00664. Epub 2016 Jan 7. Mol Pharm. 2016. PMID: 26696140

5

Comparison of the Predictability of Human Hepatic Clearance for Organic Anion Transporting Polypeptide Substrate Drugs Between Different In Vitro-In Vivo Extrapolation Approaches.

Izumi S, Nozaki Y, Komori T, Takenaka O, Maeda K, Kusuhara H, Sugiyama Y. Izumi S, et al. J Pharm Sci. 2017 Sep;106(9):2678-2687. doi: 10.1016/j.xphs.2017.02.012. Epub 2017 Feb 24. J Pharm Sci. 2017. PMID: 28238896

6

Relative Activity Factor (RAF)-Based Scaling of Uptake Clearance Mediated by Organic Anion Transporting Polypeptide (OATP) 1B1 and OATP1B3 in Human Hepatocytes.

Izumi S, Nozaki Y, Kusuhara H, Hotta K, Mochizuki T, Komori T, Maeda K, Sugiyama Y. Izumi S, et al. Mol Pharm. 2018 Jun 4;15(6):2277-2288. doi: 10.1021/acs.molpharmaceut.8b00138. Epub 2018 May 16. Mol Pharm. 2018. PMID: 29746136

7

Relative Activity Factor (RAF)-Based Scaling of Uptake Clearance Mediated by Organic Anion Transporting Polypeptide (OATP) 1B1 and OATP1B3 in Human Hepatocytes.

Izumi S, Nozaki Y, Kusuhara H, Hotta K, Mochizuki T, Komori T, Maeda K, Sugiyama Y. Izumi S, et al. Mol Pharm. 2020 Feb 3;17(2):722-723. doi: 10.1021/acs.molpharmaceut.0c00025. Epub 2020 Jan 21. Mol Pharm. 2020. PMID: 31961160 No abstract available.

8

Human Immortalized Cell-Based Blood-Brain Barrier Spheroid Models Offer an Evaluation Tool for the Brain Penetration Properties of Macromolecules.

Kitamura K, Okamoto A, Morio H, Isogai R, Ito R, Yamaura Y, Izumi S, Komori T, Ito S, Ohtsuki S, Akita H, Furihata T. Kitamura K, et al. Among authors: izumi s. Mol Pharm. 2022 Aug 1;19(8):2754-2764. doi: 10.1021/acs.molpharmaceut.2c00120. Epub 2022 Jun 29. Mol Pharm. 2022. PMID: 35766901

9

Recent advances in preclinical in vitro approaches towards quantitative prediction of hepatic clearance and drug-drug interactions involving organic anion transporting polypeptide (OATP) 1B transporters.

Nozaki Y, Izumi S. Nozaki Y, et al. Among authors: izumi s. Drug Metab Pharmacokinet. 2020 Feb;35(1):56-70. doi: 10.1016/j.dmpk.2019.11.004. Epub 2019 Dec 20. Drug Metab Pharmacokinet. 2020. PMID: 31901416 Review.

10

Experimental and Modeling Evidence Supporting the Trans-Inhibition Mechanism for Preincubation Time-Dependent, Long-Lasting Inhibition of Organic Anion Transporting Polypeptide 1B1 by Cyclosporine A.

Izumi S, Nozaki Y, Lee W, Sugiyama Y. Izumi S, et al. Drug Metab Dispos. 2022 May;50(5):541-551. doi: 10.1124/dmd.121.000783. Epub 2022 Mar 3. Drug Metab Dispos. 2022. PMID: 35241487

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