Smith B - Search Results

1

Organic Anion-Transporting Polypeptide Genes Are Not Induced by the Pregnane X Receptor Activator Rifampin: Studies in Hepatocytes In Vitro and in Monkeys In Vivo.

Niu C, Wang Y, Zhao X, Tep S, Murakami E, Subramanian R, Smith B, Lai Y. Niu C, et al. Among authors: smith b. Drug Metab Dispos. 2019 Dec;47(12):1433-1442. doi: 10.1124/dmd.119.088922. Epub 2019 Oct 3. Drug Metab Dispos. 2019. PMID: 31582395

2

Prediction of Drug-Drug Interactions with Crizotinib as the CYP3A Substrate Using a Physiologically Based Pharmacokinetic Model.

Yamazaki S, Johnson TR, Smith BJ. Yamazaki S, et al. Drug Metab Dispos. 2015 Oct;43(10):1417-29. doi: 10.1124/dmd.115.064618. Epub 2015 Jul 15. Drug Metab Dispos. 2015. PMID: 26180127 Clinical Trial.

3

Pharmacokinetics and Disposition of Momelotinib Revealed a Disproportionate Human Metabolite-Resolution for Clinical Development.

Zheng J, Xin Y, Zhang J, Subramanian R, Murray BP, Whitney JA, Warr MR, Ling J, Moorehead L, Kwan E, Hemenway J, Smith BJ, Silverman JA. Zheng J, et al. Drug Metab Dispos. 2018 Mar;46(3):237-247. doi: 10.1124/dmd.117.078899. Epub 2018 Jan 8. Drug Metab Dispos. 2018. PMID: 29311136

4

Regional Proteomic Quantification of Clinically Relevant Non-Cytochrome P450 Enzymes along the Human Small Intestine.

Zhang H, Wolford C, Basit A, Li AP, Fan PW, Murray BP, Takahashi RH, Khojasteh SC, Smith BJ, Thummel KE, Prasad B. Zhang H, et al. Among authors: smith bj. Drug Metab Dispos. 2020 Jul;48(7):528-536. doi: 10.1124/dmd.120.090738. Epub 2020 Apr 29. Drug Metab Dispos. 2020. PMID: 32350063

5

Characterization of Seasonal Pharmacokinetic Variability in Woodchucks.

Zheng J, Balsitis S, Santos R, Smith BJ, Subramanian R. Zheng J, et al. Drug Metab Dispos. 2020 Nov;48(11):1199-1209. doi: 10.1124/dmd.120.000140. Epub 2020 Sep 5. Drug Metab Dispos. 2020. PMID: 32892154

6

In Vitro Hepatic Uptake in Human and Monkey Hepatocytes in the Presence and Absence of Serum Protein and Its In Vitro to In Vivo Extrapolation.

Liang X, Park Y, DeForest N, Hao J, Zhao X, Niu C, Wang K, Smith B, Lai Y. Liang X, et al. Among authors: smith b. Drug Metab Dispos. 2020 Dec;48(12):1283-1292. doi: 10.1124/dmd.120.000163. Epub 2020 Oct 9. Drug Metab Dispos. 2020. PMID: 33037043

7

Transporter Gene Regulation in Sandwich Cultured Human Hepatocytes Through the Activation of Constitutive Androstane Receptor (CAR) or Aryl Hydrocarbon Receptor (AhR).

Niu C, Smith B, Lai Y. Niu C, et al. Among authors: smith b. Front Pharmacol. 2021 Jan 21;11:620197. doi: 10.3389/fphar.2020.620197. eCollection 2020. Front Pharmacol. 2021. PMID: 33551819 Free PMC article.

8

Key Metabolic Enzymes Involved in Remdesivir Activation in Human Lung Cells.

Li R, Liclican A, Xu Y, Pitts J, Niu C, Zhang J, Kim C, Zhao X, Soohoo D, Babusis D, Yue Q, Ma B, Murray BP, Subramanian R, Xie X, Zou J, Bilello JP, Li L, Schultz BE, Sakowicz R, Smith BJ, Shi PY, Murakami E, Feng JY. Li R, et al. Among authors: smith bj. Antimicrob Agents Chemother. 2021 Aug 17;65(9):e0060221. doi: 10.1128/AAC.00602-21. Epub 2021 Aug 17. Antimicrob Agents Chemother. 2021. PMID: 34125594 Free PMC article.

9

Inhaled remdesivir reduces viral burden in a nonhuman primate model of SARS-CoV-2 infection.

Vermillion MS, Murakami E, Ma B, Pitts J, Tomkinson A, Rautiola D, Babusis D, Irshad H, Seigel D, Kim C, Zhao X, Niu C, Yang J, Gigliotti A, Kadrichu N, Bilello JP, Ellis S, Bannister R, Subramanian R, Smith B, Mackman RL, Lee WA, Kuehl PJ, Hartke J, Cihlar T, Porter DP. Vermillion MS, et al. Among authors: smith b. Sci Transl Med. 2022 Feb 23;14(633):eabl8282. doi: 10.1126/scitranslmed.abl8282. Epub 2022 Feb 23. Sci Transl Med. 2022. PMID: 34968150 Free PMC article.

10

Comparison of Tissue Abundance of Non-Cytochrome P450 Drug-Metabolizing Enzymes by Quantitative Proteomics between Humans and Laboratory Animal Species.

Basit A, Fan PW, Khojasteh SC, Murray BP, Smith BJ, Heyward S, Prasad B. Basit A, et al. Among authors: smith bj. Drug Metab Dispos. 2022 Mar;50(3):197-203. doi: 10.1124/dmd.121.000774. Epub 2021 Dec 30. Drug Metab Dispos. 2022. PMID: 34969659

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