Karnitz LM - Search Results

1

ZC3H18 specifically binds and activates the BRCA1 promoter to facilitate homologous recombination in ovarian cancer.

Kanakkanthara A, Huntoon CJ, Hou X, Zhang M, Heinzen EP, O'Brien DR, Oberg AL, John Weroha S, Kaufmann SH, Karnitz LM. Kanakkanthara A, et al. Among authors: karnitz lm. Nat Commun. 2019 Oct 11;10(1):4632. doi: 10.1038/s41467-019-12610-x. Nat Commun. 2019. PMID: 31604914 Free PMC article.

2

BRCA1 Deficiency Upregulates NNMT, Which Reprograms Metabolism and Sensitizes Ovarian Cancer Cells to Mitochondrial Metabolic Targeting Agents.

Kanakkanthara A, Kurmi K, Ekstrom TL, Hou X, Purfeerst ER, Heinzen EP, Correia C, Huntoon CJ, O'Brien D, Wahner Hendrickson AE, Dowdy SC, Li H, Oberg AL, Hitosugi T, Kaufmann SH, Weroha SJ, Karnitz LM. Kanakkanthara A, et al. Among authors: karnitz lm. Cancer Res. 2019 Dec 1;79(23):5920-5929. doi: 10.1158/0008-5472.CAN-19-1405. Epub 2019 Oct 16. Cancer Res. 2019. PMID: 31619387 Free PMC article.

3

RAD18-mediated ubiquitination of PCNA activates the Fanconi anemia DNA repair network.

Geng L, Huntoon CJ, Karnitz LM. Geng L, et al. Among authors: karnitz lm. J Cell Biol. 2010 Oct 18;191(2):249-57. doi: 10.1083/jcb.201005101. Epub 2010 Oct 11. J Cell Biol. 2010. PMID: 20937699 Free PMC article.

4

Poly(ADP-Ribose) polymerase inhibition synergizes with 5-fluorodeoxyuridine but not 5-fluorouracil in ovarian cancer cells.

Huehls AM, Wagner JM, Huntoon CJ, Geng L, Erlichman C, Patel AG, Kaufmann SH, Karnitz LM. Huehls AM, et al. Among authors: karnitz lm. Cancer Res. 2011 Jul 15;71(14):4944-54. doi: 10.1158/0008-5472.CAN-11-0814. Epub 2011 May 25. Cancer Res. 2011. PMID: 21613406 Free PMC article.

5

Identification of DNA repair pathways that affect the survival of ovarian cancer cells treated with a poly(ADP-ribose) polymerase inhibitor in a novel drug combination.

Huehls AM, Wagner JM, Huntoon CJ, Karnitz LM. Huehls AM, et al. Among authors: karnitz lm. Mol Pharmacol. 2012 Oct;82(4):767-76. doi: 10.1124/mol.112.080614. Epub 2012 Jul 25. Mol Pharmacol. 2012. PMID: 22833573 Free PMC article.

6

ATR inhibition broadly sensitizes ovarian cancer cells to chemotherapy independent of BRCA status.

Huntoon CJ, Flatten KS, Wahner Hendrickson AE, Huehls AM, Sutor SL, Kaufmann SH, Karnitz LM. Huntoon CJ, et al. Among authors: karnitz lm. Cancer Res. 2013 Jun 15;73(12):3683-91. doi: 10.1158/0008-5472.CAN-13-0110. Epub 2013 Apr 2. Cancer Res. 2013. PMID: 23548269 Free PMC article.

7

Ovarian cancer-associated mutations disable catalytic activity of CDK12, a kinase that promotes homologous recombination repair and resistance to cisplatin and poly(ADP-ribose) polymerase inhibitors.

Joshi PM, Sutor SL, Huntoon CJ, Karnitz LM. Joshi PM, et al. Among authors: karnitz lm. J Biol Chem. 2014 Mar 28;289(13):9247-53. doi: 10.1074/jbc.M114.551143. Epub 2014 Feb 19. J Biol Chem. 2014. PMID: 24554720 Free PMC article.

8

Genomically Incorporated 5-Fluorouracil that Escapes UNG-Initiated Base Excision Repair Blocks DNA Replication and Activates Homologous Recombination.

Huehls AM, Huntoon CJ, Joshi PM, Baehr CA, Wagner JM, Wang X, Lee MY, Karnitz LM. Huehls AM, et al. Among authors: karnitz lm. Mol Pharmacol. 2016 Jan;89(1):53-62. doi: 10.1124/mol.115.100164. Epub 2015 Oct 22. Mol Pharmacol. 2016. PMID: 26494862 Free PMC article.

9

VLX600 Disrupts Homologous Recombination and Synergizes with PARP Inhibitors and Cisplatin by Inhibiting Histone Lysine Demethylases.

Ekstrom TL, Pathoulas NM, Huehls AM, Kanakkanthara A, Karnitz LM. Ekstrom TL, et al. Among authors: karnitz lm. Mol Cancer Ther. 2021 Sep;20(9):1561-1571. doi: 10.1158/1535-7163.MCT-20-1099. Epub 2021 Jun 17. Mol Cancer Ther. 2021. PMID: 34224364 Free PMC article.

10

Repurposing Ceritinib Induces DNA Damage and Enhances PARP Inhibitor Responses in High-Grade Serous Ovarian Carcinoma.

Kanakkanthara A, Hou X, Ekstrom TL, Zanfagnin V, Huehls AM, Kelly RL, Ding H, Larson MC, Vasmatzis G, Oberg AL, Kaufmann SH, Mansfield AS, Weroha SJ, Karnitz LM. Kanakkanthara A, et al. Among authors: karnitz lm. Cancer Res. 2022 Jan 15;82(2):307-319. doi: 10.1158/0008-5472.CAN-21-0732. Epub 2021 Nov 22. Cancer Res. 2022. PMID: 34810199 Free PMC article.

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