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Functional Genomic Screen in Mesothelioma Reveals that Loss of Function of BRCA1-Associated Protein 1 Induces Chemoresistance to Ribonucleotide Reductase Inhibition.
Okonska A, Bühler S, Rao V, Ronner M, Blijlevens M, van der Meulen-Muileman IH, de Menezes RX, Wipplinger M, Oehl K, Smit EF, Weder W, Stahel RA, Penengo L, van Beusechem VW, Felley-Bosco E. Okonska A, et al. Among authors: de menezes rx. Mol Cancer Ther. 2020 Feb;19(2):552-563. doi: 10.1158/1535-7163.MCT-19-0356. Epub 2019 Oct 16. Mol Cancer Ther. 2020. PMID: 31619462
Targeting JNK-interacting-protein-1 (JIP1) sensitises osteosarcoma to doxorubicin.
Posthumadeboer J, van Egmond PW, Helder MN, de Menezes RX, Cleton-Jansen AM, Beliën JA, Verheul HM, van Royen BJ, Kaspers GJ, van Beusechem VW. Posthumadeboer J, et al. Among authors: de menezes rx. Oncotarget. 2012 Oct;3(10):1169-81. doi: 10.18632/oncotarget.600. Oncotarget. 2012. PMID: 23045411 Free PMC article.
Defective sister chromatid cohesion is synthetically lethal with impaired APC/C function.
de Lange J, Faramarz A, Oostra AB, de Menezes RX, van der Meulen IH, Rooimans MA, Rockx DA, Brakenhoff RH, van Beusechem VW, King RW, de Winter JP, Wolthuis RMF. de Lange J, et al. Among authors: de menezes rx, de winter jp. Nat Commun. 2015 Oct 1;6:8399. doi: 10.1038/ncomms9399. Nat Commun. 2015. PMID: 26423134 Free PMC article.
A genome-wide siRNA screen for regulators of tumor suppressor p53 activity in human non-small cell lung cancer cells identifies components of the RNA splicing machinery as targets for anticancer treatment.
Siebring-van Olst E, Blijlevens M, de Menezes RX, van der Meulen-Muileman IH, Smit EF, van Beusechem VW. Siebring-van Olst E, et al. Among authors: de menezes rx. Mol Oncol. 2017 May;11(5):534-551. doi: 10.1002/1878-0261.12052. Epub 2017 Apr 11. Mol Oncol. 2017. PMID: 28296343 Free PMC article.
67 results