van Aalten DMF - Search Results

1

A missense mutation in the catalytic domain of O-GlcNAc transferase links perturbations in protein O-GlcNAcylation to X-linked intellectual disability.

Pravata VM, Gundogdu M, Bartual SG, Ferenbach AT, Stavridis M, Õunap K, Pajusalu S, Žordania R, Wojcik MH, van Aalten DMF. Pravata VM, et al. Among authors: van aalten dmf. FEBS Lett. 2020 Feb;594(4):717-727. doi: 10.1002/1873-3468.13640. Epub 2019 Nov 7. FEBS Lett. 2020. PMID: 31627256 Free PMC article.

2

Structural insights into mechanism and specificity of O-GlcNAc transferase.

Clarke AJ, Hurtado-Guerrero R, Pathak S, Schüttelkopf AW, Borodkin V, Shepherd SM, Ibrahim AF, van Aalten DM. Clarke AJ, et al. EMBO J. 2008 Oct 22;27(20):2780-8. doi: 10.1038/emboj.2008.186. Epub 2008 Sep 25. EMBO J. 2008. PMID: 18818698 Free PMC article.

3

Screening-based discovery of drug-like O-GlcNAcase inhibitor scaffolds.

Dorfmueller HC, van Aalten DM. Dorfmueller HC, et al. FEBS Lett. 2010 Feb 19;584(4):694-700. doi: 10.1016/j.febslet.2009.12.020. Epub 2009 Dec 16. FEBS Lett. 2010. PMID: 20026047 Free PMC article.

4

Substrate and product analogues as human O-GlcNAc transferase inhibitors.

Dorfmueller HC, Borodkin VS, Blair DE, Pathak S, Navratilova I, van Aalten DM. Dorfmueller HC, et al. Amino Acids. 2011 Mar;40(3):781-92. doi: 10.1007/s00726-010-0688-y. Epub 2010 Jul 17. Amino Acids. 2011. PMID: 20640461 Free PMC article.

5

Purification, crystallization and preliminary X-ray diffraction data of UDP-galactopyranose mutase from Aspergillus fumigatus.

Penman GA, Lockhart DE, Ferenbach A, van Aalten DM. Penman GA, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Jun 1;68(Pt 6):705-8. doi: 10.1107/S1744309112017915. Epub 2012 May 23. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012. PMID: 22684076 Free PMC article.

6

O-GlcNAc transferase invokes nucleotide sugar pyrophosphate participation in catalysis.

Schimpl M, Zheng X, Borodkin VS, Blair DE, Ferenbach AT, Schüttelkopf AW, Navratilova I, Aristotelous T, Albarbarawi O, Robinson DA, Macnaughtan MA, van Aalten DM. Schimpl M, et al. Nat Chem Biol. 2012 Dec;8(12):969-74. doi: 10.1038/nchembio.1108. Epub 2012 Oct 28. Nat Chem Biol. 2012. PMID: 23103942 Free PMC article.

7

Structure of a bacterial putative acetyltransferase defines the fold of the human O-GlcNAcase C-terminal domain.

Rao FV, Schüttelkopf AW, Dorfmueller HC, Ferenbach AT, Navratilova I, van Aalten DM. Rao FV, et al. Open Biol. 2013 Oct 2;3(10):130021. doi: 10.1098/rsob.130021. Open Biol. 2013. PMID: 24088714 Free PMC article.

8

Bisubstrate UDP-peptide conjugates as human O-GlcNAc transferase inhibitors.

Borodkin VS, Schimpl M, Gundogdu M, Rafie K, Dorfmueller HC, Robinson DA, van Aalten DM. Borodkin VS, et al. Biochem J. 2014 Feb 1;457(3):497-502. doi: 10.1042/BJ20131272. Biochem J. 2014. PMID: 24256146 Free PMC article.

9

Elevated O-GlcNAc levels activate epigenetically repressed genes and delay mouse ESC differentiation without affecting naïve to primed cell transition.

Speakman CM, Domke TC, Wongpaiboonwattana W, Sanders K, Mudaliar M, van Aalten DM, Barton GJ, Stavridis MP. Speakman CM, et al. Stem Cells. 2014 Oct;32(10):2605-15. doi: 10.1002/stem.1761. Stem Cells. 2014. PMID: 24898611 Free PMC article.

10

A structural and biochemical model of processive chitin synthesis.

Dorfmueller HC, Ferenbach AT, Borodkin VS, van Aalten DMF. Dorfmueller HC, et al. Among authors: van aalten dmf. J Biol Chem. 2014 Aug 15;289(33):23020-23028. doi: 10.1074/jbc.M114.563353. Epub 2014 Jun 18. J Biol Chem. 2014. PMID: 24942743 Free PMC article.

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