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Semisynthesis and biological evaluation of amidochelocardin derivatives as broad-spectrum antibiotics.
Grandclaudon C, Birudukota NVS, Elgaher WAM, Jumde RP, Yahiaoui S, Arisetti N, Hennessen F, Hüttel S, Stadler M, Herrmann J, Miethke M, Hartmann RW, Müller R, Hirsch AKH, Brönstrup M. Grandclaudon C, et al. Among authors: hirsch akh. Eur J Med Chem. 2020 Feb 15;188:112005. doi: 10.1016/j.ejmech.2019.112005. Epub 2019 Dec 20. Eur J Med Chem. 2020. PMID: 31911294
Rapid Discovery of Aspartyl Protease Inhibitors Using an Anchoring Approach.
Konstantinidou M, Magari F, Sutanto F, Haupenthal J, Jumde VR, Ünver MY, Heine A, Camacho CJ, Hirsch AKH, Klebe G, Dömling A. Konstantinidou M, et al. Among authors: hirsch akh. ChemMedChem. 2020 Apr 20;15(8):680-684. doi: 10.1002/cmdc.202000024. Epub 2020 Mar 18. ChemMedChem. 2020. PMID: 32187447 Free PMC article.
Protein-Templated Hit Identification through an Ugi Four-Component Reaction*.
Mancini F, Unver MY, Elgaher WAM, Jumde VR, Alhayek A, Lukat P, Herrmann J, Witte MD, Köck M, Blankenfeldt W, Müller R, Hirsch AKH. Mancini F, et al. Among authors: hirsch akh. Chemistry. 2020 Nov 17;26(64):14585-14593. doi: 10.1002/chem.202002250. Epub 2020 Sep 30. Chemistry. 2020. PMID: 32428268 Free PMC article.
N-Aryl-3-mercaptosuccinimides as Antivirulence Agents Targeting Pseudomonas aeruginosa Elastase and Clostridium Collagenases.
Konstantinović J, Yahiaoui S, Alhayek A, Haupenthal J, Schönauer E, Andreas A, Kany AM, Müller R, Koehnke J, Berger FK, Bischoff M, Hartmann RW, Brandstetter H, Hirsch AKH. Konstantinović J, et al. Among authors: hirsch akh. J Med Chem. 2020 Aug 13;63(15):8359-8368. doi: 10.1021/acs.jmedchem.0c00584. Epub 2020 Jun 17. J Med Chem. 2020. PMID: 32470298 Free PMC article.
Evaluation of Bacterial RNA Polymerase Inhibitors in a Staphylococcus aureus-Based Wound Infection Model in SKH1 Mice.
Haupenthal J, Kautz Y, Elgaher WAM, Pätzold L, Röhrig T, Laschke MW, Tschernig T, Hirsch AKH, Molodtsov V, Murakami KS, Hartmann RW, Bischoff M. Haupenthal J, et al. Among authors: hirsch akh. ACS Infect Dis. 2020 Oct 9;6(10):2573-2581. doi: 10.1021/acsinfecdis.0c00034. Epub 2020 Sep 21. ACS Infect Dis. 2020. PMID: 32886885 Free PMC article.
163 results