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Synthesis and Structure-Activity Relationships of N-(4-Benzamidino)-Oxazolidinones: Potent and Selective Inhibitors of Kallikrein-Related Peptidase 6.
De Vita E, Smits N, van den Hurk H, Beck EM, Hewitt J, Baillie G, Russell E, Pannifer A, Hamon V, Morrison A, McElroy SP, Jones P, Ignatenko NA, Gunkel N, Miller AK. De Vita E, et al. Among authors: gunkel n. ChemMedChem. 2020 Jan 7;15(1):79-95. doi: 10.1002/cmdc.201900536. Epub 2019 Nov 18. ChemMedChem. 2020. PMID: 31675166 Free PMC article.
Design and Synthesis of Dihydroxamic Acids as HDAC6/8/10 Inhibitors.
Morgen M, Steimbach RR, Géraldy M, Hellweg L, Sehr P, Ridinger J, Witt O, Oehme I, Herbst-Gervasoni CJ, Osko JD, Porter NJ, Christianson DW, Gunkel N, Miller AK. Morgen M, et al. Among authors: gunkel n. ChemMedChem. 2020 Jul 3;15(13):1163-1174. doi: 10.1002/cmdc.202000149. Epub 2020 May 13. ChemMedChem. 2020. PMID: 32348628 Free PMC article.
First Fluorescent Acetylspermidine Deacetylation Assay for HDAC10 Identifies Selective Inhibitors with Cellular Target Engagement.
Herp D, Ridinger J, Robaa D, Shinsky SA, Schmidtkunz K, Yesiloglu TZ, Bayer T, Steimbach RR, Herbst-Gervasoni CJ, Merz A, Romier C, Sehr P, Gunkel N, Miller AK, Christianson DW, Oehme I, Sippl W, Jung M. Herp D, et al. Among authors: gunkel n. Chembiochem. 2022 Jul 19;23(14):e202200180. doi: 10.1002/cbic.202200180. Epub 2022 Jun 10. Chembiochem. 2022. PMID: 35608330 Free PMC article.
Aza-SAHA Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout.
Steimbach RR, Herbst-Gervasoni CJ, Lechner S, Stewart TM, Klinke G, Ridinger J, Géraldy MNE, Tihanyi G, Foley JR, Uhrig U, Kuster B, Poschet G, Casero RA Jr, Médard G, Oehme I, Christianson DW, Gunkel N, Miller AK. Steimbach RR, et al. Among authors: gunkel n. J Am Chem Soc. 2022 Oct 19;144(41):18861-18875. doi: 10.1021/jacs.2c05030. Epub 2022 Oct 6. J Am Chem Soc. 2022. PMID: 36200994 Free PMC article.
27 results