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Novel Inhibitors of Fatty Acid Synthase with Anticancer Activity.
Puig T, Turrado C, Benhamú B, Aguilar H, Relat J, Ortega-Gutiérrez S, Casals G, Marrero PF, Urruticoechea A, Haro D, López-Rodríguez ML, Colomer R. Puig T, et al. Among authors: colomer r. Clin Cancer Res. 2009 Dec 15;15(24):7608-7615. doi: 10.1158/1078-0432.CCR-09-0856. Clin Cancer Res. 2009. PMID: 20008854
A novel inhibitor of fatty acid synthase shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines.
Puig T, Aguilar H, Cufí S, Oliveras G, Turrado C, Ortega-Gutiérrez S, Benhamú B, López-Rodríguez ML, Urruticoechea A, Colomer R. Puig T, et al. Among authors: colomer r. Breast Cancer Res. 2011;13(6):R131. doi: 10.1186/bcr3077. Epub 2011 Dec 16. Breast Cancer Res. 2011. PMID: 22177475 Free PMC article.
New synthetic inhibitors of fatty acid synthase with anticancer activity.
Turrado C, Puig T, García-Cárceles J, Artola M, Benhamú B, Ortega-Gutiérrez S, Relat J, Oliveras G, Blancafort A, Haro D, Marrero PF, Colomer R, López-Rodríguez ML. Turrado C, et al. Among authors: colomer r. J Med Chem. 2012 Jun 14;55(11):5013-23. doi: 10.1021/jm2016045. Epub 2012 May 16. J Med Chem. 2012. PMID: 22559865
Selective activity over a constitutively active RET-variant of the oral multikinase inhibitor dovitinib: results of the CNIO-BR002 phase I-trial.
Quintela-Fandino M, Bueno MJ, Lombardia L, Gil M, Gonzalez-Martin A, Marquez R, Bratos R, Guerra J, Tan E, Lopez A, Colomer R, Salazar R. Quintela-Fandino M, et al. Among authors: colomer r. Mol Oncol. 2014 Dec;8(8):1719-28. doi: 10.1016/j.molonc.2014.07.005. Epub 2014 Jul 17. Mol Oncol. 2014. PMID: 25103625 Free PMC article. Clinical Trial.
Fatty acid synthase is a metabolic marker of cell proliferation rather than malignancy in ovarian cancer and its precursor cells.
Veigel D, Wagner R, Stübiger G, Wuczkowski M, Filipits M, Horvat R, Benhamú B, López-Rodríguez ML, Leisser A, Valent P, Grusch M, Hegardt FG, García J, Serra D, Auersperg N, Colomer R, Grunt TW. Veigel D, et al. Among authors: colomer r. Int J Cancer. 2015 May 1;136(9):2078-90. doi: 10.1002/ijc.29261. Epub 2014 Nov 3. Int J Cancer. 2015. PMID: 25302649 Free article.
211 results