McAvoy K - Search Results

1

Glial mitochondrial function and dysfunction in health and neurodegeneration.

McAvoy K, Kawamata H. McAvoy K, et al. Mol Cell Neurosci. 2019 Dec;101:103417. doi: 10.1016/j.mcn.2019.103417. Epub 2019 Oct 31. Mol Cell Neurosci. 2019. PMID: 31678567 Review.

2

Mutant CHCHD10 causes an extensive metabolic rewiring that precedes OXPHOS dysfunction in a murine model of mitochondrial cardiomyopathy.

Sayles NM, Southwell N, McAvoy K, Kim K, Pesini A, Anderson CJ, Quinzii C, Cloonan S, Kawamata H, Manfredi G. Sayles NM, et al. Among authors: mcavoy k. Cell Rep. 2022 Mar 8;38(10):110475. doi: 10.1016/j.celrep.2022.110475. Cell Rep. 2022. PMID: 35263592 Free PMC article.

3

Mouse midbrain dopaminergic neurons survive loss of the PD-associated mitochondrial protein CHCHD2.

Nguyen MK, McAvoy K, Liao SC, Doric Z, Lo I, Li H, Manfredi G, Nakamura K. Nguyen MK, et al. Among authors: mcavoy k. Hum Mol Genet. 2022 May 4;31(9):1500-1518. doi: 10.1093/hmg/ddab329. Hum Mol Genet. 2022. PMID: 34791217 Free PMC article.

4

Targeting TNFα produced by astrocytes expressing amyotrophic lateral sclerosis-linked mutant fused in sarcoma prevents neurodegeneration and motor dysfunction in mice.

Jensen BK, McAvoy KJ, Heinsinger NM, Lepore AC, Ilieva H, Haeusler AR, Trotti D, Pasinelli P. Jensen BK, et al. Among authors: mcavoy kj. Glia. 2022 Jul;70(7):1426-1449. doi: 10.1002/glia.24183. Epub 2022 Apr 26. Glia. 2022. PMID: 35474517 Free PMC article.

5

Astrocytes drive upregulation of the multidrug resistance transporter ABCB1 (P-Glycoprotein) in endothelial cells of the blood-brain barrier in mutant superoxide dismutase 1-linked amyotrophic lateral sclerosis.

Qosa H, Lichter J, Sarlo M, Markandaiah SS, McAvoy K, Richard JP, Jablonski MR, Maragakis NJ, Pasinelli P, Trotti D. Qosa H, et al. Among authors: mcavoy k. Glia. 2016 Aug;64(8):1298-313. doi: 10.1002/glia.23003. Epub 2016 May 9. Glia. 2016. PMID: 27158936 Free PMC article.

6

Astrocytes expressing ALS-linked mutant FUS induce motor neuron death through release of tumor necrosis factor-alpha.

Kia A, McAvoy K, Krishnamurthy K, Trotti D, Pasinelli P. Kia A, et al. Among authors: mcavoy k. Glia. 2018 May;66(5):1016-1033. doi: 10.1002/glia.23298. Epub 2018 Jan 30. Glia. 2018. PMID: 29380416 Free PMC article.

7

Synaptic dysfunction induced by glycine-alanine dipeptides in C9orf72-ALS/FTD is rescued by SV2 replenishment.

Jensen BK, Schuldi MH, McAvoy K, Russell KA, Boehringer A, Curran BM, Krishnamurthy K, Wen X, Westergard T, Ma L, Haeusler AR, Edbauer D, Pasinelli P, Trotti D. Jensen BK, et al. Among authors: mcavoy k. EMBO Mol Med. 2020 May 8;12(5):e10722. doi: 10.15252/emmm.201910722. Epub 2020 Apr 29. EMBO Mol Med. 2020. PMID: 32347002 Free PMC article.

8

Repeat-associated non-AUG translation in C9orf72-ALS/FTD is driven by neuronal excitation and stress.

Westergard T, McAvoy K, Russell K, Wen X, Pang Y, Morris B, Pasinelli P, Trotti D, Haeusler A. Westergard T, et al. Among authors: mcavoy k. EMBO Mol Med. 2019 Feb;11(2):e9423. doi: 10.15252/emmm.201809423. EMBO Mol Med. 2019. PMID: 30617154 Free PMC article.

9

Pur-alpha regulates cytoplasmic stress granule dynamics and ameliorates FUS toxicity.

Daigle JG, Krishnamurthy K, Ramesh N, Casci I, Monaghan J, McAvoy K, Godfrey EW, Daniel DC, Johnson EM, Monahan Z, Shewmaker F, Pasinelli P, Pandey UB. Daigle JG, et al. Among authors: mcavoy k. Acta Neuropathol. 2016 Apr;131(4):605-20. doi: 10.1007/s00401-015-1530-0. Epub 2016 Jan 4. Acta Neuropathol. 2016. PMID: 26728149 Free PMC article.

10

CHCHD2 mutant mice display mitochondrial protein accumulation and disrupted energy metabolism.

Liao SC, Kano K, Phanse S, Nguyen M, Margolis E, Fu Y, Meng J, Moutaoufik MT, Chatterton Z, Aoki H, Simms J, Hsieh I, Suteja F, Sei Y, Huang EJ, McAvoy K, Manfredi G, Halliday G, Babu M, Nakamura K. Liao SC, et al. Among authors: mcavoy k. bioRxiv [Preprint]. 2024 Aug 31:2024.08.30.610586. doi: 10.1101/2024.08.30.610586. bioRxiv. 2024. PMID: 39257750 Free PMC article. Preprint.

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