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Page 1
BCL11A +58/+55 enhancer-editing facilitates HSPC engraftment and HbF induction in rhesus macaques conditioned with a CD45 antibody-drug conjugate.
Demirci S, Zeng J, Palchaudhuri R, Wu C, Abraham DM, Hayal TB, Essawi K, Nguyen MA, Stasula U, Chu R, Leonard A, Porter SN, Khan MBN, Hinojosa G, Uchida N, Hong S, Lazzarotto CR, Neri NR, da Silva LF, Pellin D, Verma A, Lanieri L, Bhat A, Hammond K, Tate T, Maitland SA, Sheikhsaran F, Bonifacino AC, Krouse AE, Linde NS, Engels T, Golomb J, Tsai SQ, Pruett-Miller SM, Scadden DT, Dunbar CE, Wolfe SA, Donahue RE, Olson LM, Bauer DE, Tisdale JF. Demirci S, et al. Among authors: scadden dt. Cell Stem Cell. 2024 Dec 5:S1934-5909(24)00376-X. doi: 10.1016/j.stem.2024.10.014. Online ahead of print. Cell Stem Cell. 2024. PMID: 39642886
Cell of origin epigenetic priming determines susceptibility to Tet2 mutation.
Schiroli G, Kartha V, Duarte FM, Kristiansen TA, Mayerhofer C, Shrestha R, Earl A, Hu Y, Tay T, Rhee C, Buenrostro JD, Scadden DT. Schiroli G, et al. Among authors: scadden dt. Nat Commun. 2024 May 21;15(1):4325. doi: 10.1038/s41467-024-48508-6. Nat Commun. 2024. PMID: 38773071 Free PMC article.
Cyclophilin A supports translation of intrinsically disordered proteins and affects haematopoietic stem cell ageing.
Maneix L, Iakova P, Lee CG, Moree SE, Lu X, Datar GK, Hill CT, Spooner E, King JCK, Sykes DB, Saez B, Di Stefano B, Chen X, Krause DS, Sahin E, Tsai FTF, Goodell MA, Berk BC, Scadden DT, Catic A. Maneix L, et al. Among authors: scadden dt. Nat Cell Biol. 2024 Apr;26(4):593-603. doi: 10.1038/s41556-024-01387-x. Epub 2024 Mar 29. Nat Cell Biol. 2024. PMID: 38553595 Free PMC article.
Leukemia aggressiveness is driven by chromatin remodeling and expression changes of core regulators.
Bonilla G, Morris A, Kundu S, DuCasse A, Kirkpatrick G, Jeffries NE, Chetal K, Yvanovich EE, Milosevic J, Zhao T, Xia J, Barghout R, Scadden D, Mansour MK, Kingston RE, Sykes DB, Mercier FE, Sadreyev RI. Bonilla G, et al. Among authors: scadden d. bioRxiv [Preprint]. 2024 Nov 20:2024.02.29.582846. doi: 10.1101/2024.02.29.582846. bioRxiv. 2024. PMID: 38496490 Free PMC article. Preprint.
A mitochondrial NADPH-cholesterol axis regulates extracellular vesicle biogenesis to support hematopoietic stem cell fate.
Bonora M, Morganti C, van Gastel N, Ito K, Calura E, Zanolla I, Ferroni L, Zhang Y, Jung Y, Sales G, Martini P, Nakamura T, Lasorsa FM, Finkel T, Lin CP, Zavan B, Pinton P, Georgakoudi I, Romualdi C, Scadden DT, Ito K. Bonora M, et al. Among authors: scadden dt. Cell Stem Cell. 2024 Mar 7;31(3):359-377.e10. doi: 10.1016/j.stem.2024.02.004. Cell Stem Cell. 2024. PMID: 38458178 Free article.
Alloengraftment without significant toxicity or GVHD in CD45 antibody-drug conjugate-conditioned Fanconi anemia mice.
Saha A, Palchaudhuri R, Lanieri L, Hyzy S, Riddle MJ, Panthera J, Eide CR, Tolar J, Panoskaltsis-Mortari A, Gorfinkel L, Tkachev V, Gerdemann U, Alvarez-Calderon F, Palato ER, MacMillan ML, Wagner JE, Kean LS, Osborn MJ, Kiem HP, Scadden DT, Olson LM, Blazar BR. Saha A, et al. Among authors: scadden dt. Blood. 2024 May 23;143(21):2201-2216. doi: 10.1182/blood.2023023549. Blood. 2024. PMID: 38447038
Stromal Cell Isolation from Hematopoietic Organs.
Kristiansen T, Mayerhofer C, Gustafsson K, Scadden DT. Kristiansen T, et al. Among authors: scadden dt. J Vis Exp. 2024 Jan 26;(203). doi: 10.3791/66231. J Vis Exp. 2024. PMID: 38345255
Bone marrow adipocytes fuel emergency hematopoiesis after myocardial infarction.
Zhang S, Paccalet A, Rohde D, Cremer S, Hulsmans M, Lee IH, Mentkowski K, Grune J, Schloss MJ, Honold L, Iwamoto Y, Zheng Y, Bredella MA, Buckless C, Ghoshhajra B, Thondapu V, van der Laan AM, Piek JJ, Niessen HWM, Pallante F, Carnevale R, Perrotta S, Carnevale D, Iborra-Egea O, Muñoz-Guijosa C, Galvez-Monton C, Bayes-Genis A, Vidoudez C, Trauger SA, Scadden D, Swirski FK, Moskowitz MA, Naxerova K, Nahrendorf M. Zhang S, et al. Among authors: scadden d. Nat Cardiovasc Res. 2023 Dec;2(12):1277-1290. doi: 10.1038/s44161-023-00388-7. Epub 2023 Dec 5. Nat Cardiovasc Res. 2023. PMID: 38344689 Free PMC article.
Single-cell analysis of immune and stroma cell remodeling in clear cell renal cell carcinoma primary tumors and bone metastatic lesions.
Mei S, Alchahin AM, Tsea I, Kfoury Y, Hirz T, Jeffries NE, Zhao T, Xu Y, Zhang H, Sarkar H, Wu S, Subtelny AO, Johnsen JI, Zhang Y, Salari K, Wu CL, Randolph MA, Scadden DT, Dahl DM, Shin J, Kharchenko PV, Saylor PJ, Sykes DB, Baryawno N. Mei S, et al. Among authors: scadden dt. Genome Med. 2024 Jan 29;16(1):1. doi: 10.1186/s13073-023-01272-6. Genome Med. 2024. PMID: 38281962 Free PMC article.
414 results