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TREM-1 multimerization is essential for its activation on monocytes and neutrophils.
Carrasco K, Boufenzer A, Jolly L, Le Cordier H, Wang G, Heck AJ, Cerwenka A, Vinolo E, Nazabal A, Kriznik A, Launay P, Gibot S, Derive M. Carrasco K, et al. Cell Mol Immunol. 2019 May;16(5):460-472. doi: 10.1038/s41423-018-0003-5. Epub 2018 Mar 22. Cell Mol Immunol. 2019. PMID: 29568119 Free PMC article.
Potentiation of NETs release is novel characteristic of TREM-1 activation and the pharmacological inhibition of TREM-1 could prevent from the deleterious consequences of NETs release in sepsis.
Boufenzer A, Carrasco K, Jolly L, Brustolin B, Di-Pillo E, Derive M, Gibot S. Boufenzer A, et al. Among authors: carrasco k. Cell Mol Immunol. 2021 Feb;18(2):452-460. doi: 10.1038/s41423-020-00591-7. Epub 2021 Jan 8. Cell Mol Immunol. 2021. PMID: 33420354 Free PMC article.
sTREM-1 is a specific biomarker of TREM-1 pathway activation.
Jolly L, Carrasco K, Salcedo-Magguilli M, Garaud JJ, Lambden S, van der Poll T, Mebazaa A, Laterre PF, Gibot S, Boufenzer A, Derive M. Jolly L, et al. Among authors: carrasco k. Cell Mol Immunol. 2021 Aug;18(8):2054-2056. doi: 10.1038/s41423-021-00733-5. Epub 2021 Jul 19. Cell Mol Immunol. 2021. PMID: 34282296 Free PMC article. No abstract available.
The potential of targeting TREM-1 in IBD.
Vinolo E, Maillefer M, Jolly L, Colné N, Meiffren G, Carrasco K, Derive M. Vinolo E, et al. Among authors: carrasco k. Adv Pharmacol. 2024;101:301-330. doi: 10.1016/bs.apha.2024.10.010. Epub 2024 Oct 24. Adv Pharmacol. 2024. PMID: 39521605 Review.
38 results