Cochran JR - Search Results

1

Antitumor activity of an engineered decoy receptor targeting CLCF1-CNTFR signaling in lung adenocarcinoma.

Kim JW, Marquez CP, Kostyrko K, Koehne AL, Marini K, Simpson DR, Lee AG, Leung SG, Sayles LC, Shrager J, Ferrer I, Paz-Ares L, Gephart MH, Vicent S, Cochran JR, Sweet-Cordero EA. Kim JW, et al. Among authors: cochran jr. Nat Med. 2019 Nov;25(11):1783-1795. doi: 10.1038/s41591-019-0612-2. Epub 2019 Nov 7. Nat Med. 2019. PMID: 31700175 Free PMC article.

2

An engineered Axl 'decoy receptor' effectively silences the Gas6-Axl signaling axis.

Kariolis MS, Miao YR, Jones DS 2nd, Kapur S, Mathews II, Giaccia AJ, Cochran JR. Kariolis MS, et al. Among authors: cochran jr. Nat Chem Biol. 2014 Nov;10(11):977-83. doi: 10.1038/nchembio.1636. Epub 2014 Sep 21. Nat Chem Biol. 2014. PMID: 25242553 Free PMC article.

3

A chemically cross-linked knottin dimer binds integrins with picomolar affinity and inhibits tumor cell migration and proliferation.

Kim JW, Cochran FV, Cochran JR. Kim JW, et al. Among authors: cochran fv, cochran jr. J Am Chem Soc. 2015 Jan 14;137(1):6-9. doi: 10.1021/ja508416e. Epub 2014 Dec 22. J Am Chem Soc. 2015. PMID: 25486381 Free PMC article.

4

Targeting ligand-receptor interactions for development of cancer therapeutics.

Kim JW, Cochran JR. Kim JW, et al. Among authors: cochran jr. Curr Opin Chem Biol. 2017 Jun;38:62-69. doi: 10.1016/j.cbpa.2017.03.010. Epub 2017 Mar 31. Curr Opin Chem Biol. 2017. PMID: 28371692 Review.

5

Engineering a potent receptor superagonist or antagonist from a novel IL-6 family cytokine ligand.

Kim JW, Marquez CP, Sperberg RAP, Wu J, Bae WG, Huang PS, Sweet-Cordero EA, Cochran JR. Kim JW, et al. Among authors: cochran jr. Proc Natl Acad Sci U S A. 2020 Jun 23;117(25):14110-14118. doi: 10.1073/pnas.1922729117. Epub 2020 Jun 10. Proc Natl Acad Sci U S A. 2020. PMID: 32522868 Free PMC article.

6

Anti-GD2 synergizes with CD47 blockade to mediate tumor eradication.

Theruvath J, Menard M, Smith BAH, Linde MH, Coles GL, Dalton GN, Wu W, Kiru L, Delaidelli A, Sotillo E, Silberstein JL, Geraghty AC, Banuelos A, Radosevich MT, Dhingra S, Heitzeneder S, Tousley A, Lattin J, Xu P, Huang J, Nasholm N, He A, Kuo TC, Sangalang ERB, Pons J, Barkal A, Brewer RE, Marjon KD, Vilches-Moure JG, Marshall PL, Fernandes R, Monje M, Cochran JR, Sorensen PH, Daldrup-Link HE, Weissman IL, Sage J, Majeti R, Bertozzi CR, Weiss WA, Mackall CL, Majzner RG. Theruvath J, et al. Among authors: cochran jr. Nat Med. 2022 Feb;28(2):333-344. doi: 10.1038/s41591-021-01625-x. Epub 2022 Jan 13. Nat Med. 2022. PMID: 35027753 Free PMC article.

7

An engineered interleukin-11 decoy cytokine inhibits receptor signaling and proliferation in lung adenocarcinoma.

McIntosh BJ, Hartmann GG, Yamada-Hunter SA, Liu P, Williams CF, Sage J, Cochran JR. McIntosh BJ, et al. Among authors: cochran jr. Bioeng Transl Med. 2023 Jul 18;8(6):e10573. doi: 10.1002/btm2.10573. eCollection 2023 Nov. Bioeng Transl Med. 2023. PMID: 38023717 Free PMC article.

8

The CLCF1-CNTFR axis drives an immunosuppressive tumor microenvironment and blockade enhances the effects of established cancer therapies.

Sweet-Cordero E, Marini K, Champion E, Lee A, Young I, Leung S, Mathey-Andrews N, Jacks T, Jackson P, Cochran J. Sweet-Cordero E, et al. Res Sq [Preprint]. 2024 Mar 22:rs.3.rs-4046823. doi: 10.21203/rs.3.rs-4046823/v1. Res Sq. 2024. PMID: 38562778 Free PMC article. Preprint.

9

Engineered proteins pull double duty.

Cochran JR. Cochran JR. Sci Transl Med. 2010 Feb 3;2(17):17ps5. doi: 10.1126/scitranslmed.3000276. Sci Transl Med. 2010. PMID: 20371477 Review.

10

Engineered epidermal growth factor mutants with faster binding on-rates correlate with enhanced receptor activation.

Lahti JL, Lui BH, Beck SE, Lee SS, Ly DP, Longaker MT, Yang GP, Cochran JR. Lahti JL, et al. Among authors: cochran jr. FEBS Lett. 2011 Apr 20;585(8):1135-9. doi: 10.1016/j.febslet.2011.03.044. Epub 2011 Mar 23. FEBS Lett. 2011. PMID: 21439278 Free PMC article.

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