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Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects.
Mertens J, Paquola ACM, Ku M, Hatch E, Böhnke L, Ladjevardi S, McGrath S, Campbell B, Lee H, Herdy JR, Gonçalves JT, Toda T, Kim Y, Winkler J, Yao J, Hetzer MW, Gage FH. Mertens J, et al. Cell Stem Cell. 2015 Dec 3;17(6):705-718. doi: 10.1016/j.stem.2015.09.001. Epub 2015 Oct 8. Cell Stem Cell. 2015. PMID: 26456686 Free PMC article.
Generation of functional human serotonergic neurons from fibroblasts.
Vadodaria KC, Mertens J, Paquola A, Bardy C, Li X, Jappelli R, Fung L, Marchetto MC, Hamm M, Gorris M, Koch P, Gage FH. Vadodaria KC, et al. Among authors: mertens j. Mol Psychiatry. 2016 Jan;21(1):49-61. doi: 10.1038/mp.2015.161. Epub 2015 Oct 27. Mol Psychiatry. 2016. PMID: 26503761
Mitochondrial Aging Defects Emerge in Directly Reprogrammed Human Neurons due to Their Metabolic Profile.
Kim Y, Zheng X, Ansari Z, Bunnell MC, Herdy JR, Traxler L, Lee H, Paquola ACM, Blithikioti C, Ku M, Schlachetzki JCM, Winkler J, Edenhofer F, Glass CK, Paucar AA, Jaeger BN, Pham S, Boyer L, Campbell BC, Hunter T, Mertens J, Gage FH. Kim Y, et al. Among authors: mertens j. Cell Rep. 2018 May 29;23(9):2550-2558. doi: 10.1016/j.celrep.2018.04.105. Cell Rep. 2018. PMID: 29847787 Free PMC article.
576 results