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Dysregulation of FGFR signalling by a selective inhibitor reduces germ cell survival in human fetal gonads of both sexes and alters the somatic niche in fetal testes.
Harpelunde Poulsen K, Nielsen JE, Frederiksen H, Melau C, Juul Hare K, Langhoff Thuesen L, Perlman S, Lundvall L, Mitchell RT, Juul A, Rajpert-De Meyts E, Jørgensen A. Harpelunde Poulsen K, et al. Among authors: mitchell rt. Hum Reprod. 2019 Nov 1;34(11):2228-2243. doi: 10.1093/humrep/dez191. Hum Reprod. 2019. PMID: 31734698 Free PMC article.
Sertoli cells control peritubular myoid cell fate and support adult Leydig cell development in the prepubertal testis.
Rebourcet D, O'Shaughnessy PJ, Pitetti JL, Monteiro A, O'Hara L, Milne L, Tsai YT, Cruickshanks L, Riethmacher D, Guillou F, Mitchell RT, van't Hof R, Freeman TC, Nef S, Smith LB. Rebourcet D, et al. Among authors: mitchell rt. Development. 2014 May;141(10):2139-49. doi: 10.1242/dev.107029. Development. 2014. PMID: 24803659 Free PMC article.
Comparative effects of di(n-butyl) phthalate exposure on fetal germ cell development in the rat and in human fetal testis xenografts.
van den Driesche S, McKinnell C, Calarrão A, Kennedy L, Hutchison GR, Hrabalkova L, Jobling MS, Macpherson S, Anderson RA, Sharpe RM, Mitchell RT. van den Driesche S, et al. Among authors: mitchell rt. Environ Health Perspect. 2015 Mar;123(3):223-30. doi: 10.1289/ehp.1408248. Epub 2014 Dec 16. Environ Health Perspect. 2015. PMID: 25514601 Free PMC article.
Prolonged exposure to acetaminophen reduces testosterone production by the human fetal testis in a xenograft model.
van den Driesche S, Macdonald J, Anderson RA, Johnston ZC, Chetty T, Smith LB, Mckinnell C, Dean A, Homer NZ, Jorgensen A, Camacho-Moll ME, Sharpe RM, Mitchell RT. van den Driesche S, et al. Among authors: mitchell rt. Sci Transl Med. 2015 May 20;7(288):288ra80. doi: 10.1126/scitranslmed.aaa4097. Sci Transl Med. 2015. PMID: 25995226 Free PMC article.
162 results