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N-acyl taurines are endogenous lipid messengers that improve glucose homeostasis.
Grevengoed TJ, Trammell SAJ, McKinney MK, Petersen N, Cardone RL, Svenningsen JS, Ogasawara D, Nexøe-Larsen CC, Knop FK, Schwartz TW, Kibbey RG, Cravatt BF, Gillum MP. Grevengoed TJ, et al. Among authors: schwartz tw. Proc Natl Acad Sci U S A. 2019 Dec 3;116(49):24770-24778. doi: 10.1073/pnas.1916288116. Epub 2019 Nov 18. Proc Natl Acad Sci U S A. 2019. PMID: 31740614 Free PMC article.
[Leu31, Pro34]neuropeptide Y: a specific Y1 receptor agonist.
Fuhlendorff J, Gether U, Aakerlund L, Langeland-Johansen N, Thøgersen H, Melberg SG, Olsen UB, Thastrup O, Schwartz TW. Fuhlendorff J, et al. Among authors: schwartz tw. Proc Natl Acad Sci U S A. 1990 Jan;87(1):182-6. doi: 10.1073/pnas.87.1.182. Proc Natl Acad Sci U S A. 1990. PMID: 2153286 Free PMC article.
The aromatic amino acid sensor GPR142 controls metabolism through balanced regulation of pancreatic and gut hormones.
Rudenko O, Shang J, Munk A, Ekberg JP, Petersen N, Engelstoft MS, Egerod KL, Hjorth SA, Wu M, Feng Y, Zhou YP, Mokrosinski J, Thams P, Reimann F, Gribble F, Rehfeld JF, Holst JJ, Treebak JT, Howard AD, Schwartz TW. Rudenko O, et al. Among authors: schwartz tw. Mol Metab. 2019 Jan;19:49-64. doi: 10.1016/j.molmet.2018.10.012. Epub 2018 Nov 5. Mol Metab. 2019. PMID: 30472415 Free PMC article.
Molecular dynamics-guided discovery of an ago-allosteric modulator for GPR40/FFAR1.
Lückmann M, Trauelsen M, Bentsen MA, Nissen TAD, Martins J, Fallah Z, Nygaard MM, Papaleo E, Lindorff-Larsen K, Schwartz TW, Frimurer TM. Lückmann M, et al. Among authors: schwartz tw. Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):7123-7128. doi: 10.1073/pnas.1811066116. Epub 2019 Mar 14. Proc Natl Acad Sci U S A. 2019. PMID: 30872479 Free PMC article.
Rfx6 promotes the differentiation of peptide-secreting enteroendocrine cells while repressing genetic programs controlling serotonin production.
Piccand J, Vagne C, Blot F, Meunier A, Beucher A, Strasser P, Lund ML, Ghimire S, Nivlet L, Lapp C, Petersen N, Engelstoft MS, Thibault-Carpentier C, Keime C, Correa SJ, Schreiber V, Molina N, Schwartz TW, De Arcangelis A, Gradwohl G. Piccand J, et al. Among authors: schwartz tw. Mol Metab. 2019 Nov;29:24-39. doi: 10.1016/j.molmet.2019.08.007. Epub 2019 Aug 13. Mol Metab. 2019. PMID: 31668390 Free PMC article.
367 results