Williams RL - Search Results

1

The ribosomal P-stalk couples amino acid starvation to GCN2 activation in mammalian cells.

Harding HP, Ordonez A, Allen F, Parts L, Inglis AJ, Williams RL, Ron D. Harding HP, et al. Among authors: williams rl. Elife. 2019 Nov 21;8:e50149. doi: 10.7554/eLife.50149. Elife. 2019. PMID: 31749445 Free PMC article.

2

Structures of PI4KIIIβ complexes show simultaneous recruitment of Rab11 and its effectors.

Burke JE, Inglis AJ, Perisic O, Masson GR, McLaughlin SH, Rutaganira F, Shokat KM, Williams RL. Burke JE, et al. Among authors: williams rl. Science. 2014 May 30;344(6187):1035-8. doi: 10.1126/science.1253397. Science. 2014. PMID: 24876499 Free PMC article.

3

Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention.

Bohnacker T, Prota AE, Beaufils F, Burke JE, Melone A, Inglis AJ, Rageot D, Sele AM, Cmiljanovic V, Cmiljanovic N, Bargsten K, Aher A, Akhmanova A, Díaz JF, Fabbro D, Zvelebil M, Williams RL, Steinmetz MO, Wymann MP. Bohnacker T, et al. Among authors: williams rl. Nat Commun. 2017 Mar 9;8:14683. doi: 10.1038/ncomms14683. Nat Commun. 2017. PMID: 28276440 Free PMC article.

4

Disease Variants of FGFR3 Reveal Molecular Basis for the Recognition and Additional Roles for Cdc37 in Hsp90 Chaperone System.

Bunney TD, Inglis AJ, Sanfelice D, Farrell B, Kerr CJ, Thompson GS, Masson GR, Thiyagarajan N, Svergun DI, Williams RL, Breeze AL, Katan M. Bunney TD, et al. Among authors: williams rl. Structure. 2018 Mar 6;26(3):446-458.e8. doi: 10.1016/j.str.2018.01.016. Epub 2018 Feb 22. Structure. 2018. PMID: 29478821 Free PMC article.

5

Activation of GCN2 by the ribosomal P-stalk.

Inglis AJ, Masson GR, Shao S, Perisic O, McLaughlin SH, Hegde RS, Williams RL. Inglis AJ, et al. Among authors: williams rl. Proc Natl Acad Sci U S A. 2019 Mar 12;116(11):4946-4954. doi: 10.1073/pnas.1813352116. Epub 2019 Feb 25. Proc Natl Acad Sci U S A. 2019. PMID: 30804176 Free PMC article.

6

Membrane characteristics tune activities of endosomal and autophagic human VPS34 complexes.

Ohashi Y, Tremel S, Masson GR, McGinney L, Boulanger J, Rostislavleva K, Johnson CM, Niewczas I, Clark J, Williams RL. Ohashi Y, et al. Among authors: williams rl. Elife. 2020 Jun 30;9:e58281. doi: 10.7554/eLife.58281. Elife. 2020. PMID: 32602837 Free PMC article.

7

Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace.

Heimhalt M, Berndt A, Wagstaff J, Anandapadamanaban M, Perisic O, Maslen S, McLaughlin S, Yu CW, Masson GR, Boland A, Ni X, Yamashita K, Murshudov GN, Skehel M, Freund SM, Williams RL. Heimhalt M, et al. Among authors: williams rl. Elife. 2021 Sep 14;10:e68799. doi: 10.7554/eLife.68799. Elife. 2021. PMID: 34519269 Free PMC article.

8

Oncogenic mutations mimic and enhance dynamic events in the natural activation of phosphoinositide 3-kinase p110α (PIK3CA).

Burke JE, Perisic O, Masson GR, Vadas O, Williams RL. Burke JE, et al. Among authors: williams rl. Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15259-64. doi: 10.1073/pnas.1205508109. Epub 2012 Sep 4. Proc Natl Acad Sci U S A. 2012. PMID: 22949682 Free PMC article.

9

Molecular determinants of PI3Kγ-mediated activation downstream of G-protein-coupled receptors (GPCRs).

Vadas O, Dbouk HA, Shymanets A, Perisic O, Burke JE, Abi Saab WF, Khalil BD, Harteneck C, Bresnick AR, Nürnberg B, Backer JM, Williams RL. Vadas O, et al. Among authors: williams rl. Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18862-7. doi: 10.1073/pnas.1304801110. Epub 2013 Nov 4. Proc Natl Acad Sci U S A. 2013. PMID: 24190998 Free PMC article.

10

Structural Mechanisms of PTEN Regulation.

Masson GR, Williams RL. Masson GR, et al. Among authors: williams rl. Cold Spring Harb Perspect Med. 2020 Mar 2;10(3):a036152. doi: 10.1101/cshperspect.a036152. Cold Spring Harb Perspect Med. 2020. PMID: 31636093 Free PMC article. Review.

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