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Decrease in p3-Alcβ37 and p3-Alcβ40, products of Alcadein β generated by γ-secretase cleavages, in aged monkeys and patients with Alzheimer's disease.
Hata S, Omori C, Kimura A, Saito H, Kimura N, Gupta V, Pedrini S, Hone E, Chatterjee P, Taddei K, Kasuga K, Ikeuchi T, Waragai M, Nishimura M, Hu A, Nakaya T, Meijer L, Maeda M, Yamamoto T, Masters CL, Rowe CC, Ames D, Yamamoto K, Martins RN, Gandy S, Suzuki T. Hata S, et al. Among authors: nishimura m. Alzheimers Dement (N Y). 2019 Nov 7;5:740-750. doi: 10.1016/j.trci.2019.09.015. eCollection 2019. Alzheimers Dement (N Y). 2019. PMID: 31754625 Free PMC article.
Alcadein cleavages by amyloid beta-precursor protein (APP) alpha- and gamma-secretases generate small peptides, p3-Alcs, indicating Alzheimer disease-related gamma-secretase dysfunction.
Hata S, Fujishige S, Araki Y, Kato N, Araseki M, Nishimura M, Hartmann D, Saftig P, Fahrenholz F, Taniguchi M, Urakami K, Akatsu H, Martins RN, Yamamoto K, Maeda M, Yamamoto T, Nakaya T, Gandy S, Suzuki T. Hata S, et al. Among authors: nishimura m. J Biol Chem. 2009 Dec 25;284(52):36024-36033. doi: 10.1074/jbc.M109.057497. Epub 2009 Oct 28. J Biol Chem. 2009. PMID: 19864413 Free PMC article.
Alternative processing of γ-secretase substrates in common forms of mild cognitive impairment and Alzheimer's disease: evidence for γ-secretase dysfunction.
Hata S, Fujishige S, Araki Y, Taniguchi M, Urakami K, Peskind E, Akatsu H, Araseki M, Yamamoto K, Martins RN, Maeda M, Nishimura M, Levey A, Chung KA, Montine T, Leverenz J, Fagan A, Goate A, Bateman R, Holtzman DM, Yamamoto T, Nakaya T, Gandy S, Suzuki T. Hata S, et al. Among authors: nishimura m. Ann Neurol. 2011 Jun;69(6):1026-31. doi: 10.1002/ana.22343. Ann Neurol. 2011. PMID: 21681798 Free PMC article.
Membrane-microdomain localization of amyloid β-precursor protein (APP) C-terminal fragments is regulated by phosphorylation of the cytoplasmic Thr668 residue.
Matsushima T, Saito Y, Elliott JI, Iijima-Ando K, Nishimura M, Kimura N, Hata S, Yamamoto T, Nakaya T, Suzuki T. Matsushima T, et al. Among authors: nishimura m. J Biol Chem. 2012 Jun 1;287(23):19715-24. doi: 10.1074/jbc.M111.334847. Epub 2012 Apr 17. J Biol Chem. 2012. PMID: 22511769 Free PMC article.
4,530 results