Hansen HF - Search Results

1

In vitro and in vivo properties of therapeutic oligonucleotides containing non-chiral 3' and 5' thiophosphate linkages.

Duschmalé J, Hansen HF, Duschmalé M, Koller E, Albaek N, Møller MR, Jensen K, Koch T, Wengel J, Bleicher K. Duschmalé J, et al. Among authors: hansen hf. Nucleic Acids Res. 2020 Jan 10;48(1):63-74. doi: 10.1093/nar/gkz1099. Nucleic Acids Res. 2020. PMID: 31754711 Free PMC article.

2

Identifying and avoiding off-target effects of RNase H-dependent antisense oligonucleotides in mice.

Hagedorn PH, Pontoppidan M, Bisgaard TS, Berrera M, Dieckmann A, Ebeling M, Møller MR, Hudlebusch H, Jensen ML, Hansen HF, Koch T, Lindow M. Hagedorn PH, et al. Among authors: hansen hf. Nucleic Acids Res. 2018 Jun 20;46(11):5366-5380. doi: 10.1093/nar/gky397. Nucleic Acids Res. 2018. PMID: 29790953 Free PMC article.

3

Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primates.

Straarup EM, Fisker N, Hedtjärn M, Lindholm MW, Rosenbohm C, Aarup V, Hansen HF, Ørum H, Hansen JB, Koch T. Straarup EM, et al. Among authors: hansen jb, hansen hf. Nucleic Acids Res. 2010 Nov;38(20):7100-11. doi: 10.1093/nar/gkq457. Epub 2010 Jul 8. Nucleic Acids Res. 2010. PMID: 20615897 Free PMC article.

4

In vivo uptake of antisense oligonucleotide drugs predicted by ab initio quantum mechanical calculations.

Hansen HF, Albaek N, Hansen BR, Shim I, Bohr H, Koch T. Hansen HF, et al. Sci Rep. 2021 Mar 18;11(1):6321. doi: 10.1038/s41598-021-85453-6. Sci Rep. 2021. PMID: 33737567 Free PMC article.

5

Nuclease stability of LNA oligonucleotides and LNA-DNA chimeras.

Frieden M, Hansen HF, Koch T. Frieden M, et al. Among authors: hansen hf. Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1041-3. doi: 10.1081/NCN-120022731. Nucleosides Nucleotides Nucleic Acids. 2003. PMID: 14565339

6

Expanding the design horizon of antisense oligonucleotides with alpha-L-LNA.

Frieden M, Christensen SM, Mikkelsen ND, Rosenbohm C, Thrue CA, Westergaard M, Hansen HF, Ørum H, Koch T. Frieden M, et al. Among authors: hansen hf. Nucleic Acids Res. 2003 Nov 1;31(21):6365-72. doi: 10.1093/nar/gkg820. Nucleic Acids Res. 2003. PMID: 14576324 Free PMC article.

7

Electronic Structures of LNA Phosphorothioate Oligonucleotides.

Bohr HG, Shim I, Stein C, Ørum H, Hansen HF, Koch T. Bohr HG, et al. Among authors: hansen hf. Mol Ther Nucleic Acids. 2017 Sep 15;8:428-441. doi: 10.1016/j.omtn.2017.05.011. Epub 2017 Jun 1. Mol Ther Nucleic Acids. 2017. PMID: 28918042 Free PMC article.

8

Locked nucleic acid: modality, diversity, and drug discovery.

Hagedorn PH, Persson R, Funder ED, Albæk N, Diemer SL, Hansen DJ, Møller MR, Papargyri N, Christiansen H, Hansen BR, Hansen HF, Jensen MA, Koch T. Hagedorn PH, et al. Among authors: hansen hf. Drug Discov Today. 2018 Jan;23(1):101-114. doi: 10.1016/j.drudis.2017.09.018. Epub 2017 Oct 6. Drug Discov Today. 2018. PMID: 28988994 Free article. Review.

9

New standards in LNA synthesis.

Hansen HF, Olsen O, Koch T. Hansen HF, et al. Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1273-5. doi: 10.1081/NCN-120022944. Nucleosides Nucleotides Nucleic Acids. 2003. PMID: 14565397 No abstract available.

10

Inhibition of PNA triplex formation by N4-benzoylated cytosine.

Christensen L, Hansen HF, Koch T, Nielsen PE. Christensen L, et al. Among authors: hansen hf. Nucleic Acids Res. 1998 Jun 1;26(11):2735-9. doi: 10.1093/nar/26.11.2735. Nucleic Acids Res. 1998. PMID: 9592162 Free PMC article.

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