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Page 1
Crystal structure of the M5 muscarinic acetylcholine receptor.
Vuckovic Z, Gentry PR, Berizzi AE, Hirata K, Varghese S, Thompson G, van der Westhuizen ET, Burger WAC, Rahmani R, Valant C, Langmead CJ, Lindsley CW, Baell JB, Tobin AB, Sexton PM, Christopoulos A, Thal DM. Vuckovic Z, et al. Among authors: burger wac. Proc Natl Acad Sci U S A. 2019 Dec 17;116(51):26001-26007. doi: 10.1073/pnas.1914446116. Epub 2019 Nov 26. Proc Natl Acad Sci U S A. 2019. PMID: 31772027 Free PMC article.
6-Phenylpyrimidin-4-ones as Positive Allosteric Modulators at the M1 mAChR: The Determinants of Allosteric Activity.
Jörg M, van der Westhuizen ET, Khajehali E, Burger WAC, White JM, Choy KHC, Tobin AB, Sexton PM, Valant C, Capuano B, Christopoulos A, Scammells PJ. Jörg M, et al. Among authors: burger wac. ACS Chem Neurosci. 2019 Mar 20;10(3):1099-1114. doi: 10.1021/acschemneuro.8b00613. Epub 2018 Dec 28. ACS Chem Neurosci. 2019. PMID: 30547573 Free PMC article.
Identification of a Novel Allosteric Site at the M5 Muscarinic Acetylcholine Receptor.
Burger WAC, Gentry PR, Berizzi AE, Vuckovic Z, van der Westhuizen ET, Thompson G, Yeasmin M, Lindsley CW, Sexton PM, Langmead CJ, Tobin AB, Christopoulos A, Valant C, Thal DM. Burger WAC, et al. ACS Chem Neurosci. 2021 Aug 18;12(16):3112-3123. doi: 10.1021/acschemneuro.1c00383. Epub 2021 Aug 5. ACS Chem Neurosci. 2021. PMID: 34351123 Free PMC article.
Structural basis of efficacy-driven ligand selectivity at GPCRs.
Powers AS, Pham V, Burger WAC, Thompson G, Laloudakis Y, Barnes NW, Sexton PM, Paul SM, Christopoulos A, Thal DM, Felder CC, Valant C, Dror RO. Powers AS, et al. Among authors: burger wac. Nat Chem Biol. 2023 Jul;19(7):805-814. doi: 10.1038/s41589-022-01247-5. Epub 2023 Feb 13. Nat Chem Biol. 2023. PMID: 36782010 Free PMC article.
Author Correction: Structural basis of efficacy-driven ligand selectivity at GPCRs.
Powers AS, Pham V, Burger WAC, Thompson G, Laloudakis Y, Barnes NW, Sexton PM, Paul SM, Christopoulos A, Thal DM, Felder CC, Valant C, Dror RO. Powers AS, et al. Among authors: burger wac. Nat Chem Biol. 2023 Apr;19(4):529. doi: 10.1038/s41589-023-01297-3. Nat Chem Biol. 2023. PMID: 36879062 Free PMC article. No abstract available.
Xanomeline displays concomitant orthosteric and allosteric binding modes at the M4 mAChR.
Burger WAC, Pham V, Vuckovic Z, Powers AS, Mobbs JI, Laloudakis Y, Glukhova A, Wootten D, Tobin AB, Sexton PM, Paul SM, Felder CC, Danev R, Dror RO, Christopoulos A, Valant C, Thal DM. Burger WAC, et al. Nat Commun. 2023 Sep 6;14(1):5440. doi: 10.1038/s41467-023-41199-5. Nat Commun. 2023. PMID: 37673901 Free PMC article.
Positive allosteric modulation of a GPCR ternary complex.
Burger WAC, Draper-Joyce CJ, Valant C, Christopoulos A, Thal DM. Burger WAC, et al. Sci Adv. 2024 Sep 13;10(37):eadp7040. doi: 10.1126/sciadv.adp7040. Epub 2024 Sep 11. Sci Adv. 2024. PMID: 39259792 Free PMC article.
Structure-Affinity Relationships and Structure-Kinetics Relationships of Pyrido[2,1-f]purine-2,4-dione Derivatives as Human Adenosine A3 Receptor Antagonists.
Xia L, Burger WAC, van Veldhoven JPD, Kuiper BJ, van Duijl TT, Lenselink EB, Paasman E, Heitman LH, IJzerman AP. Xia L, et al. Among authors: burger wac. J Med Chem. 2017 Sep 14;60(17):7555-7568. doi: 10.1021/acs.jmedchem.7b00950. Epub 2017 Aug 30. J Med Chem. 2017. PMID: 28806076 Free PMC article.
17 results