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Loss of tissue-nonspecific alkaline phosphatase (TNAP) enzyme activity in cerebral microvessels is coupled to persistent neuroinflammation and behavioral deficits in late sepsis.
Nwafor DC, Chakraborty S, Brichacek AL, Jun S, Gambill CA, Wang W, Engler-Chiurazzi EB, Dakhlallah D, Pinkerton AB, Millán JL, Benkovic SA, Brown CM. Nwafor DC, et al. Among authors: millan jl. Brain Behav Immun. 2020 Feb;84:115-131. doi: 10.1016/j.bbi.2019.11.016. Epub 2019 Nov 25. Brain Behav Immun. 2020. PMID: 31778743 Free PMC article.
Identification of a selective inhibitor of murine intestinal alkaline phosphatase (ML260) by concurrent ultra-high throughput screening against human and mouse isozymes.
Ardecky RJ, Bobkova EV, Kiffer-Moreira T, Brown B, Ganji S, Zou J, Pass I, Narisawa S, Iano FG, Rosenstein C, Cheltsov A, Rascon J, Hedrick M, Gasior C, Forster A, Shi S, Dahl R, Vasile S, Su Y, Sergienko E, Chung TDY, Kaunitz J, Hoylaerts MF, Pinkerton AB, Millán JL. Ardecky RJ, et al. Among authors: millan jl. Bioorg Med Chem Lett. 2014 Feb 1;24(3):1000-1004. doi: 10.1016/j.bmcl.2013.12.043. Epub 2013 Dec 19. Bioorg Med Chem Lett. 2014. PMID: 24412070 Free PMC article.
Alkaline Phosphatase and Hypophosphatasia.
Millán JL, Whyte MP. Millán JL, et al. Calcif Tissue Int. 2016 Apr;98(4):398-416. doi: 10.1007/s00223-015-0079-1. Epub 2015 Nov 21. Calcif Tissue Int. 2016. PMID: 26590809 Free PMC article. Review.
303 results