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Discovery of a novel 3,4-dimethylcinnoline carboxamide M4 positive allosteric modulator (PAM) chemotype via scaffold hopping.
Temple KJ, Engers JL, Long MF, Gregro AR, Watson KJ, Chang S, Jenkins MT, Luscombe VB, Rodriguez AL, Niswender CM, Bridges TM, Conn PJ, Engers DW, Lindsley CW. Temple KJ, et al. Among authors: watson kj. Bioorg Med Chem Lett. 2019 Nov 1;29(21):126678. doi: 10.1016/j.bmcl.2019.126678. Epub 2019 Sep 10. Bioorg Med Chem Lett. 2019. PMID: 31537424
Discovery of VU6028418: A Highly Selective and Orally Bioavailable M4 Muscarinic Acetylcholine Receptor Antagonist.
Spock M, Carter TR, Bollinger KA, Han C, Baker LA, Rodriguez AL, Peng L, Dickerson JW, Qi A, Rook JM, O'Neill JC, Watson KJ, Chang S, Bridges TM, Engers JL, Engers DW, Niswender CM, Conn PJ, Lindsley CW, Bender AM. Spock M, et al. Among authors: watson kj. ACS Med Chem Lett. 2021 Aug 2;12(8):1342-1349. doi: 10.1021/acsmedchemlett.1c00363. eCollection 2021 Aug 12. ACS Med Chem Lett. 2021. PMID: 34413964 Free PMC article.
Discovery of the First Selective M4 Muscarinic Acetylcholine Receptor Antagonists with in Vivo Antiparkinsonian and Antidystonic Efficacy.
Moehle MS, Bender AM, Dickerson JW, Foster DJ, Qi A, Cho HP, Donsante Y, Peng W, Bryant Z, Stillwell KJ, Bridges TM, Chang S, Watson KJ, O'Neill JC, Engers JL, Peng L, Rodriguez AL, Niswender CM, Lindsley CW, Hess EJ, Conn PJ, Rook JM. Moehle MS, et al. Among authors: watson kj. ACS Pharmacol Transl Sci. 2021 Aug 2;4(4):1306-1321. doi: 10.1021/acsptsci.0c00162. eCollection 2021 Aug 13. ACS Pharmacol Transl Sci. 2021. PMID: 34423268 Free PMC article.
Development of a Peripherally Restricted 5-HT2B Partial Agonist for Treatment of Pulmonary Arterial Hypertension.
Valentine MS, Bender AM, Shay S, Paffenroth KC, Gladson S, Dickerson JW, Watson KJ, Kapolka NJ, Boutaud O, Rook JM, Blackwell TS, Roth BL, Harrison FE, Austin ED, West JD, Lindsley CW, Merryman WD. Valentine MS, et al. Among authors: watson kj. JACC Basic Transl Sci. 2023 Sep 13;8(10):1379-1388. doi: 10.1016/j.jacbts.2023.06.014. eCollection 2023 Oct. JACC Basic Transl Sci. 2023. PMID: 38094686 Free PMC article.
Epigenetic signatures of attachment insecurity and childhood adversity provide evidence for role transition in the pathogenesis of perinatal depression.
Robakis TK, Zhang S, Rasgon NL, Li T, Wang T, Roth MC, Humphreys KL, Gotlib IH, Ho M, Khechaduri A, Watson K, Roat-Shumway S, Budhan VV, Davis KN, Crowe SD, Ellie Williams K, Urban AE. Robakis TK, et al. Transl Psychiatry. 2020 Feb 3;10(1):48. doi: 10.1038/s41398-020-0703-3. Transl Psychiatry. 2020. PMID: 32066670 Free PMC article.
Deciphering transcript architectural complexity in bacteria and archaea.
Mattick JSA, Bromley RE, Watson KJ, Adkins RS, Holt CI, Lebov JF, Sparklin BC, Tyson TS, Rasko DA, Dunning Hotopp JC. Mattick JSA, et al. Among authors: watson kj. mBio. 2024 Oct 16;15(10):e0235924. doi: 10.1128/mbio.02359-24. Epub 2024 Sep 17. mBio. 2024. PMID: 39287442 Free PMC article.
Common analysis of direct RNA sequencinG CUrrently leads to misidentification of m5C at GCU motifs.
Watson KJ, Bromley RE, Sparklin BC, Gasser MT, Bhattacharya T, Lebov JF, Tyson T, Dai N, Teigen LE, Graf KT, Foster JM, Michalski M, Bruno VM, Lindsey AR, Corrêa IR Jr, Hardy RW, Newton IL, Dunning Hotopp JC. Watson KJ, et al. Life Sci Alliance. 2023 Nov 29;7(2):e202302201. doi: 10.26508/lsa.202302201. Print 2024 Feb. Life Sci Alliance. 2023. PMID: 38030223 Free PMC article.
57 results