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Global redox proteome and phosphoproteome analysis reveals redox switch in Akt.
Su Z, Burchfield JG, Yang P, Humphrey SJ, Yang G, Francis D, Yasmin S, Shin SY, Norris DM, Kearney AL, Astore MA, Scavuzzo J, Fisher-Wellman KH, Wang QP, Parker BL, Neely GG, Vafaee F, Chiu J, Yeo R, Hogg PJ, Fazakerley DJ, Nguyen LK, Kuyucak S, James DE. Su Z, et al. Among authors: yang p, yang g. Nat Commun. 2019 Dec 2;10(1):5486. doi: 10.1038/s41467-019-13114-4. Nat Commun. 2019. PMID: 31792197 Free PMC article.
Akt phosphorylates insulin receptor substrate to limit PI3K-mediated PIP3 synthesis.
Kearney AL, Norris DM, Ghomlaghi M, Kin Lok Wong M, Humphrey SJ, Carroll L, Yang G, Cooke KC, Yang P, Geddes TA, Shin S, Fazakerley DJ, Nguyen LK, James DE, Burchfield JG. Kearney AL, et al. Among authors: yang p, yang g. Elife. 2021 Jul 13;10:e66942. doi: 10.7554/eLife.66942. Elife. 2021. PMID: 34253290 Free PMC article.
Dynamic adipocyte phosphoproteome reveals that Akt directly regulates mTORC2.
Humphrey SJ, Yang G, Yang P, Fazakerley DJ, Stöckli J, Yang JY, James DE. Humphrey SJ, et al. Among authors: yang p, yang jy, yang g. Cell Metab. 2013 Jun 4;17(6):1009-1020. doi: 10.1016/j.cmet.2013.04.010. Epub 2013 May 16. Cell Metab. 2013. PMID: 23684622 Free PMC article.
Personalized phosphoproteomics identifies functional signaling.
Needham EJ, Hingst JR, Parker BL, Morrison KR, Yang G, Onslev J, Kristensen JM, Højlund K, Ling NXY, Oakhill JS, Richter EA, Kiens B, Petersen J, Pehmøller C, James DE, Wojtaszewski JFP, Humphrey SJ. Needham EJ, et al. Among authors: yang g. Nat Biotechnol. 2022 Apr;40(4):576-584. doi: 10.1038/s41587-021-01099-9. Epub 2021 Dec 2. Nat Biotechnol. 2022. PMID: 34857927
Structural insights into Ras regulation by SIN1.
Zheng Y, Ding L, Meng X, Potter M, Kearney AL, Zhang J, Sun J, James DE, Yang G, Zhou C. Zheng Y, et al. Among authors: yang g. Proc Natl Acad Sci U S A. 2022 May 10;119(19):e2119990119. doi: 10.1073/pnas.2119990119. Epub 2022 May 6. Proc Natl Acad Sci U S A. 2022. PMID: 35522713 Free PMC article.
RagC phosphorylation autoregulates mTOR complex 1.
Yang G, Humphrey SJ, Murashige DS, Francis D, Wang QP, Cooke KC, Neely GG, James DE. Yang G, et al. EMBO J. 2019 Feb 1;38(3):e99548. doi: 10.15252/embj.201899548. Epub 2018 Dec 14. EMBO J. 2019. PMID: 30552228 Free PMC article.
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