West AP - Search Results

1

Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo.

Yambire KF, Rostosky C, Watanabe T, Pacheu-Grau D, Torres-Odio S, Sanchez-Guerrero A, Senderovich O, Meyron-Holtz EG, Milosevic I, Frahm J, West AP, Raimundo N. Yambire KF, et al. Among authors: west ap. Elife. 2019 Dec 3;8:e51031. doi: 10.7554/eLife.51031. Elife. 2019. PMID: 31793879 Free PMC article.

2

Mitochondrial DNA stress primes the antiviral innate immune response.

West AP, Khoury-Hanold W, Staron M, Tal MC, Pineda CM, Lang SM, Bestwick M, Duguay BA, Raimundo N, MacDuff DA, Kaech SM, Smiley JR, Means RE, Iwasaki A, Shadel GS. West AP, et al. Nature. 2015 Apr 23;520(7548):553-7. doi: 10.1038/nature14156. Epub 2015 Feb 2. Nature. 2015. PMID: 25642965 Free PMC article.

3

The Splicing Factor hnRNP M Is a Critical Regulator of Innate Immune Gene Expression in Macrophages.

West KO, Scott HM, Torres-Odio S, West AP, Patrick KL, Watson RO. West KO, et al. Among authors: west ap. Cell Rep. 2019 Nov 5;29(6):1594-1609.e5. doi: 10.1016/j.celrep.2019.09.078. Cell Rep. 2019. PMID: 31693898 Free PMC article.

4

Loss of mitochondrial ClpP, Lonp1, and Tfam triggers transcriptional induction of Rnf213, a susceptibility factor for moyamoya disease.

Key J, Maletzko A, Kohli A, Gispert S, Torres-Odio S, Wittig I, Heidler J, Bárcena C, López-Otín C, Lei Y, West AP, Münch C, Auburger G. Key J, et al. Among authors: west ap. Neurogenetics. 2020 Jul;21(3):187-203. doi: 10.1007/s10048-020-00609-2. Epub 2020 Apr 28. Neurogenetics. 2020. PMID: 32342250 Free PMC article.

5

TRIM14 Is a Key Regulator of the Type I IFN Response during Mycobacterium tuberculosis Infection.

Hoffpauir CT, Bell SL, West KO, Jing T, Wagner AR, Torres-Odio S, Cox JS, West AP, Li P, Patrick KL, Watson RO. Hoffpauir CT, et al. Among authors: west ap, west ko. J Immunol. 2020 Jul 1;205(1):153-167. doi: 10.4049/jimmunol.1901511. Epub 2020 May 13. J Immunol. 2020. PMID: 32404352 Free PMC article.

6

Loss of Mitochondrial Protease CLPP Activates Type I IFN Responses through the Mitochondrial DNA-cGAS-STING Signaling Axis.

Torres-Odio S, Lei Y, Gispert S, Maletzko A, Key J, Menissy SS, Wittig I, Auburger G, West AP. Torres-Odio S, et al. Among authors: west ap. J Immunol. 2021 Apr 15;206(8):1890-1900. doi: 10.4049/jimmunol.2001016. Epub 2021 Mar 17. J Immunol. 2021. PMID: 33731338 Free PMC article.

7

Elevated type I interferon responses potentiate metabolic dysfunction, inflammation, and accelerated aging in mtDNA mutator mice.

Lei Y, Guerra Martinez C, Torres-Odio S, Bell SL, Birdwell CE, Bryant JD, Tong CW, Watson RO, West LC, West AP. Lei Y, et al. Among authors: west lc, west ap. Sci Adv. 2021 May 26;7(22):eabe7548. doi: 10.1126/sciadv.abe7548. Print 2021 May. Sci Adv. 2021. PMID: 34039599 Free PMC article.

8

Increased presence of nuclear DNAJA3 and upregulation of cytosolic STAT1 and of nucleic acid sensors trigger innate immunity in the ClpP-null mouse.

Maletzko A, Key J, Wittig I, Gispert S, Koepf G, Canet-Pons J, Torres-Odio S, West AP, Auburger G. Maletzko A, et al. Among authors: west ap. Neurogenetics. 2021 Oct;22(4):297-312. doi: 10.1007/s10048-021-00657-2. Epub 2021 Aug 3. Neurogenetics. 2021. PMID: 34345994 Free PMC article.

9

Inactivity of Peptidase ClpP Causes Primary Accumulation of Mitochondrial Disaggregase ClpX with Its Interacting Nucleoid Proteins, and of mtDNA.

Key J, Torres-Odio S, Bach NC, Gispert S, Koepf G, Reichlmeir M, West AP, Prokisch H, Freisinger P, Newman WG, Shalev S, Sieber SA, Wittig I, Auburger G. Key J, et al. Among authors: west ap. Cells. 2021 Nov 29;10(12):3354. doi: 10.3390/cells10123354. Cells. 2021. PMID: 34943861 Free PMC article.

10

Assessing Mitochondrial DNA Release into the Cytosol and Subsequent Activation of Innate Immune-related Pathways in Mammalian Cells.

Bryant JD, Lei Y, VanPortfliet JJ, Winters AD, West AP. Bryant JD, et al. Among authors: west ap. Curr Protoc. 2022 Feb;2(2):e372. doi: 10.1002/cpz1.372. Curr Protoc. 2022. PMID: 35175686 Free PMC article.

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