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Page 1
In vitro selection predicts malaria parasite resistance to dihydroorotate dehydrogenase inhibitors in a mouse infection model.
Mandt REK, Lafuente-Monasterio MJ, Sakata-Kato T, Luth MR, Segura D, Pablos-Tanarro A, Viera S, Magan N, Ottilie S, Winzeler EA, Lukens AK, Gamo FJ, Wirth DF. Mandt REK, et al. Among authors: viera s. Sci Transl Med. 2019 Dec 4;11(521):eaav1636. doi: 10.1126/scitranslmed.aav1636. Sci Transl Med. 2019. PMID: 31801884 Free PMC article.
Novel inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with anti-malarial activity in the mouse model.
Booker ML, Bastos CM, Kramer ML, Barker RH Jr, Skerlj R, Sidhu AB, Deng X, Celatka C, Cortese JF, Guerrero Bravo JE, Crespo Llado KN, Serrano AE, Angulo-Barturen I, Jiménez-Díaz MB, Viera S, Garuti H, Wittlin S, Papastogiannidis P, Lin JW, Janse CJ, Khan SM, Duraisingh M, Coleman B, Goldsmith EJ, Phillips MA, Munoz B, Wirth DF, Klinger JD, Wiegand R, Sybertz E. Booker ML, et al. Among authors: viera s. J Biol Chem. 2010 Oct 22;285(43):33054-33064. doi: 10.1074/jbc.M110.162081. Epub 2010 Aug 11. J Biol Chem. 2010. PMID: 20702404 Free PMC article.
A new in vivo screening paradigm to accelerate antimalarial drug discovery.
Jiménez-Díaz MB, Viera S, Ibáñez J, Mulet T, Magán-Marchal N, Garuti H, Gómez V, Cortés-Gil L, Martínez A, Ferrer S, Fraile MT, Calderón F, Fernández E, Shultz LD, Leroy D, Wilson DM, García-Bustos JF, Gamo FJ, Angulo-Barturen I. Jiménez-Díaz MB, et al. Among authors: viera s. PLoS One. 2013 Jun 25;8(6):e66967. doi: 10.1371/journal.pone.0066967. Print 2013. PLoS One. 2013. PMID: 23825598 Free PMC article.
Animal models of efficacy to accelerate drug discovery in malaria.
Jiménez-Díaz MB, Viera S, Fernández-Alvaro E, Angulo-Barturen I. Jiménez-Díaz MB, et al. Among authors: viera s. Parasitology. 2014 Jan;141(1):93-103. doi: 10.1017/S0031182013000991. Epub 2013 Jun 21. Parasitology. 2014. PMID: 23789594 Review.
Improved murine model of malaria using Plasmodium falciparum competent strains and non-myelodepleted NOD-scid IL2Rgammanull mice engrafted with human erythrocytes.
Jiménez-Díaz MB, Mulet T, Viera S, Gómez V, Garuti H, Ibáñez J, Alvarez-Doval A, Shultz LD, Martínez A, Gargallo-Viola D, Angulo-Barturen I. Jiménez-Díaz MB, et al. Among authors: viera s. Antimicrob Agents Chemother. 2009 Oct;53(10):4533-6. doi: 10.1128/AAC.00519-09. Epub 2009 Jul 13. Antimicrob Agents Chemother. 2009. PMID: 19596869 Free PMC article.
Hundreds of dual-stage antimalarial molecules discovered by a functional gametocyte screen.
Miguel-Blanco C, Molina I, Bardera AI, Díaz B, de Las Heras L, Lozano S, González C, Rodrigues J, Delves MJ, Ruecker A, Colmenarejo G, Viera S, Martínez-Martínez MS, Fernández E, Baum J, Sinden RE, Herreros E. Miguel-Blanco C, et al. Among authors: viera s. Nat Commun. 2017 May 17;8:15160. doi: 10.1038/ncomms15160. Nat Commun. 2017. PMID: 28513586 Free PMC article.
A Developability-Focused Optimization Approach Allows Identification of in Vivo Fast-Acting Antimalarials: N-[3-[(Benzimidazol-2-yl)amino]propyl]amides.
Keurulainen L, Vahermo M, Puente-Felipe M, Sandoval-Izquierdo E, Crespo-Fernández B, Guijarro-López L, Huertas-Valentín L, de las Heras-Dueña L, Leino TO, Siiskonen A, Ballell-Pages L, Sanz LM, Castañeda-Casado P, Jiménez-Díaz MB, Martínez-Martínez MS, Viera S, Kiuru P, Calderón F, Yli-Kauhaluoma J. Keurulainen L, et al. Among authors: viera s. J Med Chem. 2015 Jun 11;58(11):4573-80. doi: 10.1021/acs.jmedchem.5b00114. Epub 2015 May 19. J Med Chem. 2015. PMID: 25906200
Quantitative measurement of Plasmodium-infected erythrocytes in murine models of malaria by flow cytometry using bidimensional assessment of SYTO-16 fluorescence.
Jiménez-Díaz MB, Mulet T, Gómez V, Viera S, Alvarez A, Garuti H, Vázquez Y, Fernández A, Ibáñez J, Jiménez M, Gargallo-Viola D, Angulo-Barturen I. Jiménez-Díaz MB, et al. Among authors: viera s. Cytometry A. 2009 Mar;75(3):225-35. doi: 10.1002/cyto.a.20647. Cytometry A. 2009. PMID: 18785271 Free article.
New molecular settings to support in vivo anti-malarial assays.
Bahamontes-Rosa N, Alejandre AR, Gomez V, Viera S, Gomez-Lorenzo MG, Sanz-Alonso LM, Mendoza-Losana A. Bahamontes-Rosa N, et al. Among authors: viera s. Malar J. 2016 Mar 8;15:147. doi: 10.1186/s12936-016-1205-x. Malar J. 2016. PMID: 26955872 Free PMC article.
23 results