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Page 1
Raptor-Mediated Proteasomal Degradation of Deamidated 4E-BP2 Regulates Postnatal Neuronal Translation and NF-κB Activity.
Kouloulia S, Hallin EI, Simbriger K, Amorim IS, Lach G, Amvrosiadis T, Chalkiadaki K, Kampaite A, Truong VT, Hooshmandi M, Jafarnejad SM, Skehel P, Kursula P, Khoutorsky A, Gkogkas CG. Kouloulia S, et al. Among authors: jafarnejad sm. Cell Rep. 2019 Dec 10;29(11):3620-3635.e7. doi: 10.1016/j.celrep.2019.11.023. Cell Rep. 2019. PMID: 31825840 Free PMC article.
Pharmacogenetic inhibition of eIF4E-dependent Mmp9 mRNA translation reverses fragile X syndrome-like phenotypes.
Gkogkas CG, Khoutorsky A, Cao R, Jafarnejad SM, Prager-Khoutorsky M, Giannakas N, Kaminari A, Fragkouli A, Nader K, Price TJ, Konicek BW, Graff JR, Tzinia AK, Lacaille JC, Sonenberg N. Gkogkas CG, et al. Among authors: jafarnejad sm. Cell Rep. 2014 Dec 11;9(5):1742-1755. doi: 10.1016/j.celrep.2014.10.064. Epub 2014 Nov 26. Cell Rep. 2014. PMID: 25466251 Free PMC article.
Translational control of nociception via 4E-binding protein 1.
Khoutorsky A, Bonin RP, Sorge RE, Gkogkas CG, Pawlowski SA, Jafarnejad SM, Pitcher MH, Alain T, Perez-Sanchez J, Salter EW, Martin L, Ribeiro-da-Silva A, De Koninck Y, Cervero F, Mogil JS, Sonenberg N. Khoutorsky A, et al. Among authors: jafarnejad sm. Elife. 2015 Dec 18;4:e12002. doi: 10.7554/eLife.12002. Elife. 2015. PMID: 26678009 Free PMC article.
eIF2α phosphorylation controls thermal nociception.
Khoutorsky A, Sorge RE, Prager-Khoutorsky M, Pawlowski SA, Longo G, Jafarnejad SM, Tahmasebi S, Martin LJ, Pitcher MH, Gkogkas CG, Sharif-Naeini R, Ribeiro-da-Silva A, Bourque CW, Cervero F, Mogil JS, Sonenberg N. Khoutorsky A, et al. Among authors: jafarnejad sm. Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):11949-11954. doi: 10.1073/pnas.1614047113. Epub 2016 Oct 3. Proc Natl Acad Sci U S A. 2016. PMID: 27698114 Free PMC article.
Control of embryonic stem cell self-renewal and differentiation via coordinated alternative splicing and translation of YY2.
Tahmasebi S, Jafarnejad SM, Tam IS, Gonatopoulos-Pournatzis T, Matta-Camacho E, Tsukumo Y, Yanagiya A, Li W, Atlasi Y, Caron M, Braunschweig U, Pearl D, Khoutorsky A, Gkogkas CG, Nadon R, Bourque G, Yang XJ, Tian B, Stunnenberg HG, Yamanaka Y, Blencowe BJ, Giguère V, Sonenberg N. Tahmasebi S, et al. Among authors: jafarnejad sm. Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12360-12367. doi: 10.1073/pnas.1615540113. Epub 2016 Oct 24. Proc Natl Acad Sci U S A. 2016. PMID: 27791185 Free PMC article.
Cap-binding protein 4EHP effects translation silencing by microRNAs.
Chapat C, Jafarnejad SM, Matta-Camacho E, Hesketh GG, Gelbart IA, Attig J, Gkogkas CG, Alain T, Stern-Ginossar N, Fabian MR, Gingras AC, Duchaine TF, Sonenberg N. Chapat C, et al. Among authors: jafarnejad sm. Proc Natl Acad Sci U S A. 2017 May 23;114(21):5425-5430. doi: 10.1073/pnas.1701488114. Epub 2017 May 9. Proc Natl Acad Sci U S A. 2017. PMID: 28487484 Free PMC article.
Metformin ameliorates core deficits in a mouse model of fragile X syndrome.
Gantois I, Khoutorsky A, Popic J, Aguilar-Valles A, Freemantle E, Cao R, Sharma V, Pooters T, Nagpal A, Skalecka A, Truong VT, Wiebe S, Groves IA, Jafarnejad SM, Chapat C, McCullagh EA, Gamache K, Nader K, Lacaille JC, Gkogkas CG, Sonenberg N. Gantois I, et al. Among authors: jafarnejad sm. Nat Med. 2017 Jun;23(6):674-677. doi: 10.1038/nm.4335. Epub 2017 May 15. Nat Med. 2017. PMID: 28504725 Free article.
Translational control of ERK signaling through miRNA/4EHP-directed silencing.
Jafarnejad SM, Chapat C, Matta-Camacho E, Gelbart IA, Hesketh GG, Arguello M, Garzia A, Kim SH, Attig J, Shapiro M, Morita M, Khoutorsky A, Alain T, Gkogkas CG, Stern-Ginossar N, Tuschl T, Gingras AC, Duchaine TF, Sonenberg N. Jafarnejad SM, et al. Elife. 2018 Feb 7;7:e35034. doi: 10.7554/eLife.35034. Elife. 2018. PMID: 29412140 Free PMC article.
Active-site mTOR inhibitors augment HSV1-dICP0 infection in cancer cells via dysregulated eIF4E/4E-BP axis.
Zakaria C, Sean P, Hoang HD, Leroux LP, Watson M, Workenhe ST, Hearnden J, Pearl D, Truong VT, Robichaud N, Yanagiya A, Tahmasebi S, Jafarnejad SM, Jia JJ, Pelin A, Diallo JS, Le Boeuf F, Bell JC, Mossman KL, Graber TE, Jaramillo M, Sonenberg N, Alain T. Zakaria C, et al. Among authors: jafarnejad sm. PLoS Pathog. 2018 Aug 23;14(8):e1007264. doi: 10.1371/journal.ppat.1007264. eCollection 2018 Aug. PLoS Pathog. 2018. PMID: 30138450 Free PMC article.
59 results