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HBO1 is required for the maintenance of leukaemia stem cells.
MacPherson L, Anokye J, Yeung MM, Lam EYN, Chan YC, Weng CF, Yeh P, Knezevic K, Butler MS, Hoegl A, Chan KL, Burr ML, Gearing LJ, Willson T, Liu J, Choi J, Yang Y, Bilardi RA, Falk H, Nguyen N, Stupple PA, Peat TS, Zhang M, de Silva M, Carrasco-Pozo C, Avery VM, Khoo PS, Dolezal O, Dennis ML, Nuttall S, Surjadi R, Newman J, Ren B, Leaver DJ, Sun Y, Baell JB, Dovey O, Vassiliou GS, Grebien F, Dawson SJ, Street IP, Monahan BJ, Burns CJ, Choudhary C, Blewitt ME, Voss AK, Thomas T, Dawson MA. MacPherson L, et al. Among authors: baell jb. Nature. 2020 Jan;577(7789):266-270. doi: 10.1038/s41586-019-1835-6. Epub 2019 Dec 11. Nature. 2020. PMID: 31827282
The future of chemical probes is diversity.
Müller S, Frye S, Baell J. Müller S, et al. RSC Med Chem. 2022 Nov 16;13(12):1438. doi: 10.1039/d2md90036j. eCollection 2022 Dec 14. RSC Med Chem. 2022. PMID: 36561071 Free PMC article.
Trypanothione reductase high-throughput screening campaign identifies novel classes of inhibitors with antiparasitic activity.
Holloway GA, Charman WN, Fairlamb AH, Brun R, Kaiser M, Kostewicz E, Novello PM, Parisot JP, Richardson J, Street IP, Watson KG, Baell JB. Holloway GA, et al. Among authors: baell jb. Antimicrob Agents Chemother. 2009 Jul;53(7):2824-33. doi: 10.1128/AAC.01568-08. Epub 2009 Apr 13. Antimicrob Agents Chemother. 2009. PMID: 19364854 Free PMC article.
Antimalarial 3-arylamino-6-benzylamino-1,2,4,5-tetrazines.
Nhu D, Duffy S, Avery VM, Hughes A, Baell JB. Nhu D, et al. Among authors: baell jb. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4496-8. doi: 10.1016/j.bmcl.2010.06.036. Epub 2010 Jun 10. Bioorg Med Chem Lett. 2010. PMID: 20584608
3-alkylthio-1,2,4-triazine dimers with potent antimalarial activity.
Ban K, Duffy S, Khakham Y, Avery VM, Hughes A, Montagnat O, Katneni K, Ryan E, Baell JB. Ban K, et al. Among authors: baell jb. Bioorg Med Chem Lett. 2010 Oct 15;20(20):6024-9. doi: 10.1016/j.bmcl.2010.08.065. Epub 2010 Aug 19. Bioorg Med Chem Lett. 2010. PMID: 20822904
Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity.
Sleebs BE, Czabotar PE, Fairbrother WJ, Fairlie WD, Flygare JA, Huang DC, Kersten WJ, Koehler MF, Lessene G, Lowes K, Parisot JP, Smith BJ, Smith ML, Souers AJ, Street IP, Yang H, Baell JB. Sleebs BE, et al. Among authors: baell jb. J Med Chem. 2011 Mar 24;54(6):1914-26. doi: 10.1021/jm101596e. Epub 2011 Mar 2. J Med Chem. 2011. PMID: 21366295
163 results