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Page 1
Enteroendocrine and tuft cells support Lgr5 stem cells on Paneth cell depletion.
van Es JH, Wiebrands K, López-Iglesias C, van de Wetering M, Zeinstra L, van den Born M, Korving J, Sasaki N, Peters PJ, van Oudenaarden A, Clevers H. van Es JH, et al. Proc Natl Acad Sci U S A. 2019 Dec 26;116(52):26599-26605. doi: 10.1073/pnas.1801888117. Epub 2019 Dec 16. Proc Natl Acad Sci U S A. 2019. PMID: 31843916 Free PMC article.
Reg4+ deep crypt secretory cells function as epithelial niche for Lgr5+ stem cells in colon.
Sasaki N, Sachs N, Wiebrands K, Ellenbroek SI, Fumagalli A, Lyubimova A, Begthel H, van den Born M, van Es JH, Karthaus WR, Li VS, López-Iglesias C, Peters PJ, van Rheenen J, van Oudenaarden A, Clevers H. Sasaki N, et al. Proc Natl Acad Sci U S A. 2016 Sep 13;113(37):E5399-407. doi: 10.1073/pnas.1607327113. Epub 2016 Aug 29. Proc Natl Acad Sci U S A. 2016. PMID: 27573849 Free PMC article.
Adult mouse and human organoids derived from thyroid follicular cells and modeling of Graves' hyperthyroidism.
van der Vaart J, Bosmans L, Sijbesma SF, Knoops K, van de Wetering WJ, Otten HG, Begthel H, Borel Rinkes IHM, Korving J, Lentjes EGWM, Lopez-Iglesias C, Peters PJ, van Santen HM, Vriens MR, Clevers H. van der Vaart J, et al. Proc Natl Acad Sci U S A. 2021 Dec 21;118(51):e2117017118. doi: 10.1073/pnas.2117017118. Proc Natl Acad Sci U S A. 2021. PMID: 34916298 Free PMC article.
Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formation.
He GW, Lin L, DeMartino J, Zheng X, Staliarova N, Dayton T, Begthel H, van de Wetering WJ, Bodewes E, van Zon J, Tans S, Lopez-Iglesias C, Peters PJ, Wu W, Kotlarz D, Klein C, Margaritis T, Holstege F, Clevers H. He GW, et al. Cell Stem Cell. 2022 Sep 1;29(9):1333-1345.e6. doi: 10.1016/j.stem.2022.08.002. Epub 2022 Aug 23. Cell Stem Cell. 2022. PMID: 36002022 Free PMC article.
Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids.
Hu H, Gehart H, Artegiani B, LÖpez-Iglesias C, Dekkers F, Basak O, van Es J, Chuva de Sousa Lopes SM, Begthel H, Korving J, van den Born M, Zou C, Quirk C, Chiriboga L, Rice CM, Ma S, Rios A, Peters PJ, de Jong YP, Clevers H. Hu H, et al. Cell. 2018 Nov 29;175(6):1591-1606.e19. doi: 10.1016/j.cell.2018.11.013. Cell. 2018. PMID: 30500538 Free article.
Modelling of primary ciliary dyskinesia using patient-derived airway organoids.
van der Vaart J, Böttinger L, Geurts MH, van de Wetering WJ, Knoops K, Sachs N, Begthel H, Korving J, Lopez-Iglesias C, Peters PJ, Eitan K, Gileles-Hillel A, Clevers H. van der Vaart J, et al. EMBO Rep. 2021 Dec 6;22(12):e52058. doi: 10.15252/embr.202052058. Epub 2021 Oct 25. EMBO Rep. 2021. PMID: 34693619 Free PMC article.
Probing the Tumor Suppressor Function of BAP1 in CRISPR-Engineered Human Liver Organoids.
Artegiani B, van Voorthuijsen L, Lindeboom RGH, Seinstra D, Heo I, Tapia P, López-Iglesias C, Postrach D, Dayton T, Oka R, Hu H, van Boxtel R, van Es JH, Offerhaus J, Peters PJ, van Rheenen J, Vermeulen M, Clevers H. Artegiani B, et al. Cell Stem Cell. 2019 Jun 6;24(6):927-943.e6. doi: 10.1016/j.stem.2019.04.017. Epub 2019 May 23. Cell Stem Cell. 2019. PMID: 31130514 Free article.
High-Resolution mRNA and Secretome Atlas of Human Enteroendocrine Cells.
Beumer J, Puschhof J, Bauzá-Martinez J, Martínez-Silgado A, Elmentaite R, James KR, Ross A, Hendriks D, Artegiani B, Busslinger GA, Ponsioen B, Andersson-Rolf A, Saftien A, Boot C, Kretzschmar K, Geurts MH, Bar-Ephraim YE, Pleguezuelos-Manzano C, Post Y, Begthel H, van der Linden F, Lopez-Iglesias C, van de Wetering WJ, van der Linden R, Peters PJ, Heck AJR, Goedhart J, Snippert H, Zilbauer M, Teichmann SA, Wu W, Clevers H. Beumer J, et al. Cell. 2020 Jun 11;181(6):1291-1306.e19. doi: 10.1016/j.cell.2020.04.036. Epub 2020 May 13. Cell. 2020. PMID: 32407674 Free article.
138 results