Frett B - Search Results

1

Structural Characterization of the Aurora Kinase B "DFG-flip" Using Metadynamics.

Lakkaniga NR, Balasubramaniam M, Zhang S, Frett B, Li HY. Lakkaniga NR, et al. Among authors: frett b. AAPS J. 2019 Dec 18;22(1):14. doi: 10.1208/s12248-019-0399-6. AAPS J. 2019. PMID: 31853739 Free PMC article.

2

Targeting mutant KRAS for anticancer therapeutics: a review of novel small molecule modulators.

Wang Y, Kaiser CE, Frett B, Li HY. Wang Y, et al. Among authors: frett b. J Med Chem. 2013 Jul 11;56(13):5219-30. doi: 10.1021/jm3017706. Epub 2013 Apr 23. J Med Chem. 2013. PMID: 23566315 Free PMC article. Review.

3

Targeting the K-Ras/PDEδ protein-protein interaction: the solution for Ras-driven cancers or just another therapeutic mirage?

Frett B, Wang Y, Li HY. Frett B, et al. ChemMedChem. 2013 Oct;8(10):1620-2. doi: 10.1002/cmdc.201300311. Epub 2013 Aug 12. ChemMedChem. 2013. PMID: 23939923 Free PMC article.

4

Therapeutic melting pot of never in mitosis gene a related kinase 2 (Nek2): a perspective on Nek2 as an oncology target and recent advancements in Nek2 small molecule inhibition.

Frett B, Brown RV, Ma M, Hu W, Han H, Li HY. Frett B, et al. J Med Chem. 2014 Jul 24;57(14):5835-44. doi: 10.1021/jm401719n. Epub 2014 Feb 25. J Med Chem. 2014. PMID: 24517277 Free PMC article. Review.

5

Efficient access to 2,3-diarylimidazo[1,2-a]pyridines via a one-pot, ligand-free, palladium-catalyzed three-component reaction under microwave irradiation.

Wang Y, Frett B, Li HY. Wang Y, et al. Among authors: frett b. Org Lett. 2014 Jun 6;16(11):3016-9. doi: 10.1021/ol501136e. Epub 2014 May 22. Org Lett. 2014. PMID: 24854606 Free PMC article.

6

Identification of two novel RET kinase inhibitors through MCR-based drug discovery: design, synthesis and evaluation.

Frett B, Moccia M, Carlomagno F, Santoro M, Li HY. Frett B, et al. Eur J Med Chem. 2014 Oct 30;86:714-23. doi: 10.1016/j.ejmech.2014.09.023. Epub 2014 Sep 8. Eur J Med Chem. 2014. PMID: 25232968 Free PMC article.

7

Metal-free, efficient hydrazination of imidazo[1,2-a]pyridine with diethyl azodicarboxylate in neutral media.

Wang Y, Frett B, McConnell N, Li HY. Wang Y, et al. Among authors: frett b. Org Biomol Chem. 2015 Mar 14;13(10):2958-64. doi: 10.1039/c4ob02284j. Org Biomol Chem. 2015. PMID: 25611884 Free PMC article.

8

Computer aided drug discovery of highly ligand efficient, low molecular weight imidazopyridine analogs as FLT3 inhibitors.

Frett B, McConnell N, Smith CC, Wang Y, Shah NP, Li HY. Frett B, et al. Eur J Med Chem. 2015 Apr 13;94:123-31. doi: 10.1016/j.ejmech.2015.02.052. Epub 2015 Feb 28. Eur J Med Chem. 2015. PMID: 25765758 Free PMC article.

9

Fragment-Based Discovery of a Dual pan-RET/VEGFR2 Kinase Inhibitor Optimized for Single-Agent Polypharmacology.

Frett B, Carlomagno F, Moccia ML, Brescia A, Federico G, De Falco V, Admire B, Chen Z, Qi W, Santoro M, Li HY. Frett B, et al. Angew Chem Int Ed Engl. 2015 Jul 20;54(30):8717-21. doi: 10.1002/anie.201501104. Epub 2015 Jun 30. Angew Chem Int Ed Engl. 2015. PMID: 26126987 Free PMC article.

10

Selective Reduction of Halogenated Nitroarenes with Hydrazine Hydrate in the Presence of Pd/C.

Li F, Frett B, Li HY. Li F, et al. Among authors: frett b. Synlett. 2014 Jun;25(10):1403-1408. doi: 10.1055/s-0033-1339025. Synlett. 2014. PMID: 26843785 Free PMC article.

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