Medan J - Search Results

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Formaldehyde-activated WEHI-150 induces DNA interstrand crosslinks with unique structural features.

Pumuye PP, Evison BJ, Konda SK, Collins JG, Kelso C, Medan J, Sleebs BE, Watson K, Phillips DR, Cutts SM. Pumuye PP, et al. Among authors: medan j. Bioorg Med Chem. 2020 Feb 1;28(3):115260. doi: 10.1016/j.bmc.2019.115260. Epub 2019 Dec 14. Bioorg Med Chem. 2020. PMID: 31870833

Reversible and formaldehyde-mediated covalent binding of a bis-amino mitoxantrone analogue to DNA.

Konda SK, Kelso C, Pumuye PP, Medan J, Sleebs BE, Cutts SM, Phillips DR, Collins JG. Konda SK, et al. Among authors: medan j. Org Biomol Chem. 2016 May 18;14(20):4728-38. doi: 10.1039/c6ob00561f. Org Biomol Chem. 2016. PMID: 27142235

Isolation and structural analysis of the covalent adduct formed between a bis-amino mitoxantrone analogue and DNA: a pathway to major-minor groove cross-linked adducts.

Konda SK, Kelso C, Medan J, Sleebs BE, Phillips DR, Cutts SM, Collins JG. Konda SK, et al. Among authors: medan j. Org Biomol Chem. 2016 Nov 2;14(43):10217-10221. doi: 10.1039/c6ob02100j. Org Biomol Chem. 2016. PMID: 27735959

Development of an automated assay for accelerated in vitro detection of DNA adduct-inducing and crosslinking agents.

Medan J, Sleebs BE, Lackovic K, Watson KG, Evison BJ, Phillips DR, Cutts SM. Medan J, et al. Bioorg Med Chem Lett. 2021 Mar 1;35:127813. doi: 10.1016/j.bmcl.2021.127813. Epub 2021 Jan 21. Bioorg Med Chem Lett. 2021. PMID: 33486050

Potent inhibitors of phosphatidylinositol 3 (PI3) kinase that have antiproliferative activity only when delivered as prodrug forms.

O'Brien NJ, Amran S, Medan J, Cleary B, Deady LW, Jennings IG, Thompson PE, Abbott BM. O'Brien NJ, et al. Among authors: medan j. ChemMedChem. 2013 Jun;8(6):914-8. doi: 10.1002/cmdc.201200583. Epub 2013 Apr 8. ChemMedChem. 2013. PMID: 23568455

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