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Mass spectrometry-based selectivity profiling identifies a highly selective inhibitor of the kinase MELK that delays mitotic entry in cancer cells.
McDonald IM, Grant GD, East MP, Gilbert TSK, Wilkerson EM, Goldfarb D, Beri J, Herring LE, Vaziri C, Cook JG, Emanuele MJ, Graves LM. McDonald IM, et al. Among authors: emanuele mj. J Biol Chem. 2020 Feb 21;295(8):2359-2374. doi: 10.1074/jbc.RA119.011083. Epub 2020 Jan 2. J Biol Chem. 2020. PMID: 31896573 Free PMC article.
Application of a MYC degradation screen identifies sensitivity to CDK9 inhibitors in KRAS-mutant pancreatic cancer.
Blake DR, Vaseva AV, Hodge RG, Kline MP, Gilbert TSK, Tyagi V, Huang D, Whiten GC, Larson JE, Wang X, Pearce KH, Herring LE, Graves LM, Frye SV, Emanuele MJ, Cox AD, Der CJ. Blake DR, et al. Among authors: emanuele mj. Sci Signal. 2019 Jul 16;12(590):eaav7259. doi: 10.1126/scisignal.aav7259. Sci Signal. 2019. PMID: 31311847 Free PMC article.
Ubiquitin chain-elongating enzyme UBE2S activates the RING E3 ligase APC/C for substrate priming.
Martinez-Chacin RC, Bodrug T, Bolhuis DL, Kedziora KM, Bonacci T, Ordureau A, Gibbs ME, Weissmann F, Qiao R, Grant GD, Cook JG, Peters JM, Wade Harper J, Emanuele MJ, Brown NG. Martinez-Chacin RC, et al. Among authors: emanuele mj. Nat Struct Mol Biol. 2020 Jun;27(6):550-560. doi: 10.1038/s41594-020-0424-6. Epub 2020 May 11. Nat Struct Mol Biol. 2020. PMID: 32393902 Free PMC article.
Proteomic Analysis Reveals a PLK1-Dependent G2/M Degradation Program and Links PKA-AKAP2 to Cell Cycle Control.
Mouery RD, Hsu C, Bonacci T, Bolhuis DL, Wang X, Mills CA, Toomer ED, Canterbury OG, Robertson KC, Branigan TB, Brown NG, Herring LE, Emanuele MJ. Mouery RD, et al. Among authors: emanuele mj. bioRxiv [Preprint]. 2023 Oct 12:2023.10.11.561963. doi: 10.1101/2023.10.11.561963. bioRxiv. 2023. Update in: Cell Rep. 2024 Aug 27;43(8):114510. doi: 10.1016/j.celrep.2024.114510 PMID: 37873169 Free PMC article. Updated. Preprint.
Proteomic analysis reveals a PLK1-dependent G2/M degradation program and a role for AKAP2 in coordinating the mitotic cytoskeleton.
Mouery RD, Lukasik K, Hsu C, Bonacci T, Bolhuis DL, Wang X, Mills CA, Toomer ED, Canterbury OG, Robertson KC, Branigan TB, Brown NG, Herring LE, Gupton SL, Emanuele MJ. Mouery RD, et al. Among authors: emanuele mj. Cell Rep. 2024 Aug 27;43(8):114510. doi: 10.1016/j.celrep.2024.114510. Epub 2024 Jul 16. Cell Rep. 2024. PMID: 39018246 Free PMC article.
53 results