Mao F - Search Results

1

Development of Novel N-hydroxypyridone Derivatives as Potential Anti-Ischemic Stroke Agents.

Hu L, Feng H, Zhang H, Yu S, Zhao Q, Wang W, Bao F, Ding X, Hu J, Wang M, Xu Y, Wu Z, Li X, Tang Y, Mao F, Chen X, Zhang H, Li J. Hu L, et al. Among authors: mao f. J Med Chem. 2020 Feb 13;63(3):1051-1067. doi: 10.1021/acs.jmedchem.9b01338. Epub 2020 Jan 22. J Med Chem. 2020. PMID: 31910018

2

Design, synthesis, and evaluation of indanone derivatives as acetylcholinesterase inhibitors and metal-chelating agents.

Meng FC, Mao F, Shan WJ, Qin F, Huang L, Li XS. Meng FC, et al. Among authors: mao f. Bioorg Med Chem Lett. 2012 Jul 1;22(13):4462-6. doi: 10.1016/j.bmcl.2012.04.029. Epub 2012 Apr 13. Bioorg Med Chem Lett. 2012. PMID: 22633691

3

Multitarget-directed benzylideneindanone derivatives: anti-β-amyloid (Aβ) aggregation, antioxidant, metal chelation, and monoamine oxidase B (MAO-B) inhibition properties against Alzheimer's disease.

Huang L, Lu C, Sun Y, Mao F, Luo Z, Su T, Jiang H, Shan W, Li X. Huang L, et al. Among authors: mao f. J Med Chem. 2012 Oct 11;55(19):8483-92. doi: 10.1021/jm300978h. Epub 2012 Oct 1. J Med Chem. 2012. PMID: 22978824

4

Discovery of Potent Benzocycloalkane Derived Diapophytoene Desaturase Inhibitors with an Enhanced Safety Profile for the Treatment of MRSA, VISA, and LRSA Infections.

Li B, Ni S, Chen F, Mao F, Wei H, Liu Y, Zhu J, Lan L, Li J. Li B, et al. Among authors: mao f. ACS Infect Dis. 2018 Mar 9;4(3):208-217. doi: 10.1021/acsinfecdis.7b00259. Epub 2018 Feb 12. ACS Infect Dis. 2018. PMID: 29377669

5

Novel Tadalafil Derivatives Ameliorates Scopolamine-Induced Cognitive Impairment in Mice via Inhibition of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5).

Ni W, Wang H, Li X, Zheng X, Wang M, Zhang J, Gong Q, Ling D, Mao F, Zhang H, Li J. Ni W, et al. Among authors: mao f. ACS Chem Neurosci. 2018 Jul 18;9(7):1625-1636. doi: 10.1021/acschemneuro.8b00014. Epub 2018 Apr 17. ACS Chem Neurosci. 2018. PMID: 29616790

6

Rational Design of Novel Selective Dual-Target Inhibitors of Acetylcholinesterase and Monoamine Oxidase B as Potential Anti-Alzheimer's Disease Agents.

Xu Y, Zhang J, Wang H, Mao F, Bao K, Liu W, Zhu J, Li X, Zhang H, Li J. Xu Y, et al. Among authors: mao f. ACS Chem Neurosci. 2019 Jan 16;10(1):482-496. doi: 10.1021/acschemneuro.8b00357. Epub 2018 Aug 29. ACS Chem Neurosci. 2019. PMID: 30110536

Compound 1c displayed the dual functional profile of targeting the AChE (IC(50) = 0.032 0.007 muM) and MAO-B (IC(50) = 2.117 0.061 muM), along with the improved blood-brain barrier (BBB) permeability, antioxidant ability, and good copper chelating property in vitro. Animal …

Compound 1c displayed the dual functional profile of targeting the AChE (IC(50) = 0.032 0.007 muM) and MAO-B (IC(50) = 2.117 0.061 mu …

7

Discovery of Novel Plasmodium falciparum HDAC1 Inhibitors with Dual-Stage Antimalarial Potency and Improved Safety Based on the Clinical Anticancer Drug Candidate Quisinostat.

Li R, Ling D, Tang T, Huang Z, Wang M, Ding Y, Liu T, Wei H, Xu W, Mao F, Zhu J, Li X, Jiang L, Li J. Li R, et al. Among authors: mao f. J Med Chem. 2021 Feb 25;64(4):2254-2271. doi: 10.1021/acs.jmedchem.0c02104. Epub 2021 Feb 4. J Med Chem. 2021. PMID: 33541085

8

Fangchinoline suppresses conjunctival melanoma by directly binding FUBP2 and inhibiting the homologous recombination pathway.

Bao K, Li Y, Wei J, Li R, Yang J, Shi J, Li B, Zhu J, Mao F, Jia R, Li J. Bao K, et al. Among authors: mao f. Cell Death Dis. 2021 Apr 7;12(4):380. doi: 10.1038/s41419-021-03653-4. Cell Death Dis. 2021. PMID: 33828201 Free PMC article.

9

Drug Repurposing of Quisinostat to Discover Novel Plasmodium falciparum HDAC1 Inhibitors with Enhanced Triple-Stage Antimalarial Activity and Improved Safety.

Wang M, Tang T, Li R, Huang Z, Ling D, Zheng L, Ding Y, Liu T, Xu W, Zhu F, Min H, Boonhok R, Mao F, Zhu J, Li X, Jiang L, Li J. Wang M, et al. Among authors: mao f. J Med Chem. 2022 Mar 10;65(5):4156-4181. doi: 10.1021/acs.jmedchem.1c01993. Epub 2022 Feb 17. J Med Chem. 2022. PMID: 35175762

10

Pro-senescence neddylation inhibitor combined with a senescence activated β-galactosidase prodrug to selectively target cancer cells.

Ni S, Liu Q, Chen X, Ding L, Cai L, Mao F, Shi D, Hoffman RM, Li J, Jia L. Ni S, et al. Among authors: mao f. Signal Transduct Target Ther. 2022 Sep 9;7(1):313. doi: 10.1038/s41392-022-01128-2. Signal Transduct Target Ther. 2022. PMID: 36075909 Free PMC article. No abstract available.

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