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Page 1
Neutrophil extracellular trap-associated RNA and LL37 enable self-amplifying inflammation in psoriasis.
Herster F, Bittner Z, Archer NK, Dickhöfer S, Eisel D, Eigenbrod T, Knorpp T, Schneiderhan-Marra N, Löffler MW, Kalbacher H, Vierbuchen T, Heine H, Miller LS, Hartl D, Freund L, Schäkel K, Heister M, Ghoreschi K, Weber ANR. Herster F, et al. Among authors: weber anr. Nat Commun. 2020 Jan 8;11(1):105. doi: 10.1038/s41467-019-13756-4. Nat Commun. 2020. PMID: 31913271 Free PMC article.
RNA and imidazoquinolines are sensed by distinct TLR7/8 ectodomain sites resulting in functionally disparate signaling events.
Colak E, Leslie A, Zausmer K, Khatamzas E, Kubarenko AV, Pichulik T, Klimosch SN, Mayer A, Siggs O, Hector A, Fischer R, Klesser B, Rautanen A, Frank M, Hill AV, Manoury B, Beutler B, Hartl D, Simmons A, Weber AN. Colak E, et al. J Immunol. 2014 Jun 15;192(12):5963-73. doi: 10.4049/jimmunol.1303058. Epub 2014 May 9. J Immunol. 2014. PMID: 24813206 Free PMC article.
A coding IRAK2 protein variant compromises Toll-like receptor (TLR) signaling and is associated with colorectal cancer survival.
Wang H, Flannery SM, Dickhöfer S, Huhn S, George J, Kubarenko AV, Lascorz J, Bevier M, Willemsen J, Pichulik T, Schafmayer C, Binder M, Manoury B, Paludan SR, Alarcon-Riquelme M, Bowie AG, Försti A, Weber ANR. Wang H, et al. Among authors: weber anr. J Biol Chem. 2014 Aug 15;289(33):23123-23131. doi: 10.1074/jbc.M113.492934. Epub 2014 Jun 19. J Biol Chem. 2014. PMID: 24973222 Free PMC article.
Neutrophils: Between host defence, immune modulation, and tissue injury.
Kruger P, Saffarzadeh M, Weber AN, Rieber N, Radsak M, von Bernuth H, Benarafa C, Roos D, Skokowa J, Hartl D. Kruger P, et al. PLoS Pathog. 2015 Mar 12;11(3):e1004651. doi: 10.1371/journal.ppat.1004651. eCollection 2015 Mar. PLoS Pathog. 2015. PMID: 25764063 Free PMC article. Review.
A frequent hypofunctional IRAK2 variant is associated with reduced spontaneous hepatitis C virus clearance.
Wang H, El Maadidi S, Fischer J, Grabski E, Dickhöfer S, Klimosch S, Flannery SM, Filomena A, Wolz OO, Schneiderhan-Marra N, Löffler MW, Wiese M, Pichulik T, Müllhaupt B, Semela D, Dufour JF, Bochud PY, Bowie AG, Kalinke U, Berg T, Weber AN; East-German and Swiss Hepatitis C Virus Study Groups. Wang H, et al. Hepatology. 2015 Nov;62(5):1375-87. doi: 10.1002/hep.28105. Epub 2015 Sep 28. Hepatology. 2015. PMID: 26250868
Human NACHT, LRR, and PYD domain-containing protein 3 (NLRP3) inflammasome activity is regulated by and potentially targetable through Bruton tyrosine kinase.
Liu X, Pichulik T, Wolz OO, Dang TM, Stutz A, Dillen C, Delmiro Garcia M, Kraus H, Dickhöfer S, Daiber E, Münzenmayer L, Wahl S, Rieber N, Kümmerle-Deschner J, Yazdi A, Franz-Wachtel M, Macek B, Radsak M, Vogel S, Schulte B, Walz JS, Hartl D, Latz E, Stilgenbauer S, Grimbacher B, Miller L, Brunner C, Wolz C, Weber ANR. Liu X, et al. Among authors: weber anr. J Allergy Clin Immunol. 2017 Oct;140(4):1054-1067.e10. doi: 10.1016/j.jaci.2017.01.017. Epub 2017 Feb 16. J Allergy Clin Immunol. 2017. PMID: 28216434
The fungal ligand chitin directly binds TLR2 and triggers inflammation dependent on oligomer size.
Fuchs K, Cardona Gloria Y, Wolz OO, Herster F, Sharma L, Dillen CA, Täumer C, Dickhöfer S, Bittner Z, Dang TM, Singh A, Haischer D, Schlöffel MA, Koymans KJ, Sanmuganantham T, Krach M, Roger T, Le Roy D, Schilling NA, Frauhammer F, Miller LS, Nürnberger T, LeibundGut-Landmann S, Gust AA, Macek B, Frank M, Gouttefangeas C, Dela Cruz CS, Hartl D, Weber AN. Fuchs K, et al. EMBO Rep. 2018 Dec;19(12):e46065. doi: 10.15252/embr.201846065. Epub 2018 Oct 18. EMBO Rep. 2018. PMID: 30337494 Free PMC article.
Platelets Aggregate With Neutrophils and Promote Skin Pathology in Psoriasis.
Herster F, Bittner Z, Codrea MC, Archer NK, Heister M, Löffler MW, Heumos S, Wegner J, Businger R, Schindler M, Stegner D, Schäkel K, Grabbe S, Ghoreschi K, Miller LS, Weber ANR. Herster F, et al. Among authors: weber anr. Front Immunol. 2019 Aug 16;10:1867. doi: 10.3389/fimmu.2019.01867. eCollection 2019. Front Immunol. 2019. PMID: 31474979 Free PMC article.
81 results