Shuganning injection, a traditional Chinese patent medicine, induces ferroptosis and suppresses tumor growth in triple-negative breast cancer cells.
Du J, Wang L, Huang X, Zhang N, Long Z, Yang Y, Zhong F, Zheng B, Lan W, Lin W, Ma W.
Du J, et al. Among authors: long z.
Phytomedicine. 2021 May;85:153551. doi: 10.1016/j.phymed.2021.153551. Epub 2021 Mar 18.
Phytomedicine. 2021.
PMID: 33827043
The cell death induced by SGNI in TNBC cells showed distinct morphology from apoptosis and could not be rescued by the pan-caspase inhibitor Z-VAD(OMe)-FMK. On the other hand, SGNI induced cell death was blocked by the lipid ROS scavengers ferrostatin-1 and liproxstatin-1, …
The cell death induced by SGNI in TNBC cells showed distinct morphology from apoptosis and could not be rescued by the pan-caspase inhibitor …