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Intestinal epithelial NAIP/NLRC4 restricts systemic dissemination of the adapted pathogen Salmonella Typhimurium due to site-specific bacterial PAMP expression.
Hausmann A, Böck D, Geiser P, Berthold DL, Fattinger SA, Furter M, Bouman JA, Barthel-Scherrer M, Lang CM, Bakkeren E, Kolinko I, Diard M, Bumann D, Slack E, Regoes RR, Pilhofer M, Sellin ME, Hardt WD. Hausmann A, et al. Among authors: geiser p. Mucosal Immunol. 2020 May;13(3):530-544. doi: 10.1038/s41385-019-0247-0. Epub 2020 Jan 17. Mucosal Immunol. 2020. PMID: 31953493 Free PMC article.
Epithelium-autonomous NAIP/NLRC4 prevents TNF-driven inflammatory destruction of the gut epithelial barrier in Salmonella-infected mice.
Fattinger SA, Geiser P, Samperio Ventayol P, Di Martino ML, Furter M, Felmy B, Bakkeren E, Hausmann A, Barthel-Scherrer M, Gül E, Hardt WD, Sellin ME. Fattinger SA, et al. Among authors: geiser p. Mucosal Immunol. 2021 May;14(3):615-629. doi: 10.1038/s41385-021-00381-y. Epub 2021 Mar 17. Mucosal Immunol. 2021. PMID: 33731826 Free PMC article.
Bacterial detection by NAIP/NLRC4 elicits prompt contractions of intestinal epithelial cell layers.
Samperio Ventayol P, Geiser P, Di Martino ML, Florbrant A, Fattinger SA, Walder N, Sima E, Shao F, Gekara NO, Sundbom M, Hardt WD, Webb DL, Hellström PM, Eriksson J, Sellin ME. Samperio Ventayol P, et al. Among authors: geiser p. Proc Natl Acad Sci U S A. 2021 Apr 20;118(16):e2013963118. doi: 10.1073/pnas.2013963118. Proc Natl Acad Sci U S A. 2021. PMID: 33846244 Free PMC article.
Gasdermin D is the only Gasdermin that provides protection against acute Salmonella gut infection in mice.
Fattinger SA, Maurer L, Geiser P, Bernard EM, Enz U, Ganguillet S, Gül E, Kroon S, Demarco B, Mack V, Furter M, Barthel M, Pelczar P, Shao F, Broz P, Sellin ME, Hardt WD. Fattinger SA, et al. Among authors: geiser p. Proc Natl Acad Sci U S A. 2023 Nov 28;120(48):e2315503120. doi: 10.1073/pnas.2315503120. Epub 2023 Nov 21. Proc Natl Acad Sci U S A. 2023. PMID: 37988464 Free PMC article.
34 results