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Page 1
Total Synthesis and Biological Evaluation of Natural and Designed Tubulysins.
Nicolaou KC, Yin J, Mandal D, Erande RD, Klahn P, Jin M, Aujay M, Sandoval J, Gavrilyuk J, Vourloumis D. Nicolaou KC, et al. Among authors: gavrilyuk j. J Am Chem Soc. 2016 Feb 10;138(5):1698-708. doi: 10.1021/jacs.5b12557. Epub 2016 Feb 1. J Am Chem Soc. 2016. PMID: 26829208
12,13-Aziridinyl Epothilones. Stereoselective Synthesis of Trisubstituted Olefinic Bonds from Methyl Ketones and Heteroaromatic Phosphonates and Design, Synthesis, and Biological Evaluation of Potent Antitumor Agents.
Nicolaou KC, Rhoades D, Wang Y, Bai R, Hamel E, Aujay M, Sandoval J, Gavrilyuk J. Nicolaou KC, et al. Among authors: gavrilyuk j. J Am Chem Soc. 2017 May 31;139(21):7318-7334. doi: 10.1021/jacs.7b02655. Epub 2017 May 17. J Am Chem Soc. 2017. PMID: 28513142
Streamlined Total Synthesis of Trioxacarcins and Its Application to the Design, Synthesis, and Biological Evaluation of Analogues Thereof. Discovery of Simpler Designed and Potent Trioxacarcin Analogues.
Nicolaou KC, Chen P, Zhu S, Cai Q, Erande RD, Li R, Sun H, Pulukuri KK, Rigol S, Aujay M, Sandoval J, Gavrilyuk J. Nicolaou KC, et al. Among authors: gavrilyuk j. J Am Chem Soc. 2017 Nov 1;139(43):15467-15478. doi: 10.1021/jacs.7b08820. Epub 2017 Oct 20. J Am Chem Soc. 2017. PMID: 29052423
Improved Total Synthesis of Tubulysins and Design, Synthesis, and Biological Evaluation of New Tubulysins with Highly Potent Cytotoxicities against Cancer Cells as Potential Payloads for Antibody-Drug Conjugates.
Nicolaou KC, Erande RD, Yin J, Vourloumis D, Aujay M, Sandoval J, Munneke S, Gavrilyuk J. Nicolaou KC, et al. Among authors: gavrilyuk j. J Am Chem Soc. 2018 Mar 14;140(10):3690-3711. doi: 10.1021/jacs.7b12692. Epub 2018 Jan 30. J Am Chem Soc. 2018. PMID: 29381062
Streamlined Total Synthesis of Shishijimicin A and Its Application to the Design, Synthesis, and Biological Evaluation of Analogues thereof and Practical Syntheses of PhthNSSMe and Related Sulfenylating Reagents.
Nicolaou KC, Li R, Lu Z, Pitsinos EN, Alemany LB, Aujay M, Lee C, Sandoval J, Gavrilyuk J. Nicolaou KC, et al. Among authors: gavrilyuk j. J Am Chem Soc. 2018 Sep 26;140(38):12120-12136. doi: 10.1021/jacs.8b06955. Epub 2018 Sep 14. J Am Chem Soc. 2018. PMID: 30216054
Design, Synthesis, and Biological Investigation of Epothilone B Analogues Featuring Lactone, Lactam, and Carbocyclic Macrocycles, Epoxide, Aziridine, and 1,1-Difluorocyclopropane and Other Fluorine Residues.
Nicolaou KC, Shelke YG, Dherange BD, Kempema A, Lin B, Gu C, Sandoval J, Hammond M, Aujay M, Gavrilyuk J. Nicolaou KC, et al. Among authors: gavrilyuk j. J Org Chem. 2020 Mar 6;85(5):2865-2917. doi: 10.1021/acs.joc.0c00123. Epub 2020 Feb 17. J Org Chem. 2020. PMID: 32065746
Synthesis and Biological Evaluation of Shishijimicin A-Type Linker-Drugs and Antibody-Drug Conjugates.
Nicolaou KC, Li R, Chen Q, Lu Z, Pitsinos EN, Schammel A, Lin B, Gu C, Sarvaiya H, Tchelepi R, Valdiosera A, Clubb J, Barbour N, Sisodiya V, Sandoval J, Lee C, Aujay M, Gavrilyuk J. Nicolaou KC, et al. Among authors: gavrilyuk j. J Am Chem Soc. 2020 Jul 22;142(29):12890-12899. doi: 10.1021/jacs.0c06554. Epub 2020 Jul 14. J Am Chem Soc. 2020. PMID: 32662641
32 results