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Page 1
Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model.
Meilandt WJ, Ngu H, Gogineni A, Lalehzadeh G, Lee SH, Srinivasan K, Imperio J, Wu T, Weber M, Kruse AJ, Stark KL, Chan P, Kwong M, Modrusan Z, Friedman BA, Elstrott J, Foreman O, Easton A, Sheng M, Hansen DV. Meilandt WJ, et al. Among authors: imperio j. J Neurosci. 2020 Feb 26;40(9):1956-1974. doi: 10.1523/JNEUROSCI.1871-19.2019. Epub 2020 Jan 24. J Neurosci. 2020. PMID: 31980586 Free PMC article.
Selective Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12) with Activity in a Model of Alzheimer's Disease.
Patel S, Meilandt WJ, Erickson RI, Chen J, Deshmukh G, Estrada AA, Fuji RN, Gibbons P, Gustafson A, Harris SF, Imperio J, Liu W, Liu X, Liu Y, Lyssikatos JP, Ma C, Yin J, Lewcock JW, Siu M. Patel S, et al. Among authors: imperio j. J Med Chem. 2017 Oct 12;60(19):8083-8102. doi: 10.1021/acs.jmedchem.7b00843. Epub 2017 Sep 20. J Med Chem. 2017. PMID: 28929759
Muscle specific kinase (MuSK) activation preserves neuromuscular junctions in the diaphragm but is not sufficient to provide a functional benefit in the SOD1G93A mouse model of ALS.
Sengupta-Ghosh A, Dominguez SL, Xie L, Barck KH, Jiang Z, Earr T, Imperio J, Phu L, Budayeva HG, Kirkpatrick DS, Cai H, Eastham-Anderson J, Ngu H, Foreman O, Hedehus M, Reichelt M, Hotzel I, Shang Y, Carano RAD, Ayalon G, Easton A. Sengupta-Ghosh A, et al. Among authors: imperio j. Neurobiol Dis. 2019 Apr;124:340-352. doi: 10.1016/j.nbd.2018.12.002. Epub 2018 Dec 4. Neurobiol Dis. 2019. PMID: 30528255
Corrigendum to "Muscle specific kinase (MuSK) activation preserves neuromuscular junctions in the diaphragm but is not sufficient to provide a functional benefit in the SOD1G93A mouse model of ALS" Neurobiology of Disease 124 (2019) 340-352.
Sengupta-Ghosh A, Dominguez SL, Xie L, Barck KH, Jiang Z, Earr T, Imperio J, Phu L, Budayeva HG, Kirkpatrick DS, Cai H, He D, Eastham-Anderson J, Ngu H, Foreman O, Hedehus M, Reichelt M, Hotzel I, Shang Y, Carano RAD, Ayalon G, Easton A. Sengupta-Ghosh A, et al. Among authors: imperio j. Neurobiol Dis. 2019 Dec;132:104558. doi: 10.1016/j.nbd.2019.104558. Epub 2019 Aug 27. Neurobiol Dis. 2019. PMID: 31471201 Free article. No abstract available.
Genetic inactivation of RIP1 kinase does not ameliorate disease in a mouse model of ALS.
Dominguez S, Varfolomeev E, Brendza R, Stark K, Tea J, Imperio J, Ngu H, Earr T, Foreman O, Webster JD, Easton A, Vucic D, Bingol B. Dominguez S, et al. Among authors: imperio j. Cell Death Differ. 2021 Mar;28(3):915-931. doi: 10.1038/s41418-020-00625-7. Epub 2020 Sep 29. Cell Death Differ. 2021. PMID: 32994544 Free PMC article.
Trem2 restrains the enhancement of tau accumulation and neurodegeneration by β-amyloid pathology.
Lee SH, Meilandt WJ, Xie L, Gandham VD, Ngu H, Barck KH, Rezzonico MG, Imperio J, Lalehzadeh G, Huntley MA, Stark KL, Foreman O, Carano RAD, Friedman BA, Sheng M, Easton A, Bohlen CJ, Hansen DV. Lee SH, et al. Among authors: imperio j. Neuron. 2021 Apr 21;109(8):1283-1301.e6. doi: 10.1016/j.neuron.2021.02.010. Epub 2021 Mar 5. Neuron. 2021. PMID: 33675684 Free article.
A fluorescent splice-switching mouse model enables high-throughput, sensitive quantification of antisense oligonucleotide delivery and activity.
Byrnes AE, Roudnicky F, Gogineni A, Soung AL, Xiong M, Hayne M, Heaster-Ford T, Shatz-Binder W, Dominguez SL, Imperio J, Gierke S, Roberts J, Guo J, Ghosh S, Yu C, Roose-Girma M, Elstrott J, Easton A, Hoogenraad CC. Byrnes AE, et al. Among authors: imperio j. Cell Rep Methods. 2024 Jan 22;4(1):100673. doi: 10.1016/j.crmeth.2023.100673. Epub 2024 Jan 2. Cell Rep Methods. 2024. PMID: 38171361 Free PMC article.
Neutral or Detrimental Effects of TREM2 Agonist Antibodies in Preclinical Models of Alzheimer's Disease and Multiple Sclerosis.
Etxeberria A, Shen YA, Vito S, Silverman SM, Imperio J, Lalehzadeh G, Soung AL, Du C, Xie L, Choy MK, Hsiao YC, Ngu H, Cho CH, Ghosh S, Novikova G, Rezzonico MG, Leahey R, Weber M, Gogineni A, Elstrott J, Xiong M, Greene JJ, Stark KL, Chan P, Roth GA, Adrian M, Li Q, Choi M, Wong WR, Sandoval W, Foreman O, Nugent AA, Friedman BA, Sadekar S, Hötzel I, Hansen DV, Chih B, Yuen TJ, Weimer RM, Easton A, Meilandt WJ, Bohlen CJ. Etxeberria A, et al. Among authors: imperio j. J Neurosci. 2024 Jul 17;44(29):e2347232024. doi: 10.1523/JNEUROSCI.2347-23.2024. J Neurosci. 2024. PMID: 38830764
Primate cerebrospinal fluid CHI3L1 reflects brain TREM2 agonism.
Schauer SP, Cho CH, Novikova G, Roth GA, Lee J, Sharma AD, Foley AR, Ng C, Shen P, Choi M, Ma TP, Phu L, Budayeva HG, Cheung TK, Lalehzadeh G, Imperio J, Ngu H, Etxeberria A, Liang Y, Rezzonico MG, Dourado M, Huang K, Lai Z, Hokom M, Pandya NJ, Newton D, Abdel-Haleem AM, Chan P, Lee D, Tassew NG, Sangaraju D, O'Connor D, Hötzel I, Stark KL, Chou C, Foreman O, Easton A, Wildsmith KR, Sperinde G, Rose CM, Friedman BA, Fuji RN, Weimer RM, Meilandt WJ, Sadekar S, Nugent AA, Biever A. Schauer SP, et al. Among authors: imperio j. Alzheimers Dement. 2024 Sep;20(9):5861-5888. doi: 10.1002/alz.13921. Epub 2024 Aug 1. Alzheimers Dement. 2024. PMID: 39090679 Free PMC article.
15 results