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Regulation of sarcomere formation and function in the healthy heart requires a titin intronic enhancer.
Kim Y, Kim SW, Saul D, Neyazi M, Schmid M, Wakimoto H, Slaven N, Lee JH, Layton OG, Wasson LK, Letendre JH, Xiao F, Ewoldt JK, Gkatzis K, Sommer P, Gobert B, Wiest-Daesslé N, McAfee Q, Singhal N, Lun M, Gorham JM, Arany Z, Sharma A, Toepfer CN, Oudit GY, Pu WT, Dickel DE, Pennacchio LA, Visel A, Chen CS, Seidman JG, Seidman CE. Kim Y, et al. Among authors: ewoldt jk. J Clin Invest. 2024 Dec 17:e183353. doi: 10.1172/JCI183353. Online ahead of print. J Clin Invest. 2024. PMID: 39688912 Free article.
Induced pluripotent stem cell-derived cardiomyocyte in vitro models: benchmarking progress and ongoing challenges.
Ewoldt JK, DePalma SJ, Jewett ME, Karakan MÇ, Lin YM, Mir Hashemian P, Gao X, Lou L, McLellan MA, Tabares J, Ma M, Salazar Coariti AC, He J, Toussaint KC Jr, Bifano TG, Ramaswamy S, White AE, Agarwal A, Lejeune E, Baker BM, Chen CS. Ewoldt JK, et al. Nat Methods. 2024 Nov 8. doi: 10.1038/s41592-024-02480-7. Online ahead of print. Nat Methods. 2024. PMID: 39516564 Review.
MicroBundlePillarTrack: A Python package for automated segmentation, tracking, and analysis of pillar deflection in cardiac microbundles.
Kobeissi H, Gao X, DePalma SJ, Ewoldt JK, Wang MC, Das SL, Jilberto J, Nordsletten D, Baker BM, Chen CS, Lejeune E. Kobeissi H, et al. Among authors: ewoldt jk. ArXiv [Preprint]. 2024 Aug 15:arXiv:2405.11096v2. ArXiv. 2024. Update in: MicroPubl Biol. 2024 Jul 23;2024. doi: 10.17912/micropub.biology.001231 PMID: 39184538 Free PMC article. Updated. Preprint.
MicroBundlePillarTrack: A Python package for automated segmentation, tracking, and analysis of pillar deflection in cardiac microbundles.
Kobeissi H, Gao X, DePalma SJ, Ewoldt JK, Wang MC, Das SL, Jilberto J, Nordsletten D, Baker BM, Chen CS, Lejeune E. Kobeissi H, et al. Among authors: ewoldt jk. MicroPubl Biol. 2024 Jul 23;2024:10.17912/micropub.biology.001231. doi: 10.17912/micropub.biology.001231. eCollection 2024. MicroPubl Biol. 2024. PMID: 39114859 Free PMC article.
Plakophilin-2 truncating variants impair cardiac contractility by disrupting sarcomere stability and organization.
Zhang K, Cloonan PE, Sundaram S, Liu F, Das SL, Ewoldt JK, Bays JL, Tomp S, Toepfer CN, Marsiglia JDC, Gorham J, Reichart D, Eyckmans J, Seidman JG, Seidman CE, Chen CS. Zhang K, et al. Among authors: ewoldt jk. Sci Adv. 2021 Oct 15;7(42):eabh3995. doi: 10.1126/sciadv.abh3995. Epub 2021 Oct 15. Sci Adv. 2021. PMID: 34652945 Free PMC article.
Probing the subcellular nanostructure of engineered human cardiomyocytes in 3D tissue.
Javor J, Ewoldt JK, Cloonan PE, Chopra A, Luu RJ, Freychet G, Zhernenkov M, Ludwig K, Seidman JG, Seidman CE, Chen CS, Bishop DJ. Javor J, et al. Among authors: ewoldt jk. Microsyst Nanoeng. 2021 Jan 27;7:10. doi: 10.1038/s41378-020-00234-x. eCollection 2021. Microsyst Nanoeng. 2021. PMID: 34567727 Free PMC article.
15 results