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Discovery and Optimization of Triazine Nitrile Inhibitors of Toxoplasma gondii Cathepsin L for the Potential Treatment of Chronic Toxoplasmosis in the CNS.
Zwicker JD, Smith D, Guerra AJ, Hitchens JR, Haug N, Vander Roest S, Lee P, Wen B, Sun D, Wang L, Keep RF, Xiang J, Carruthers VB, Larsen SD. Zwicker JD, et al. Among authors: larsen sd. ACS Chem Neurosci. 2020 Aug 19;11(16):2450-2463. doi: 10.1021/acschemneuro.9b00674. Epub 2020 Feb 18. ACS Chem Neurosci. 2020. PMID: 32027110 Free PMC article.
Small molecule screening identifies regulators of the transcription factor ΔFosB.
Wang Y, Cesena TI, Ohnishi Y, Burger-Caplan R, Lam V, Kirchhoff PD, Larsen SD, Larsen MJ, Nestler EJ, Rudenko G. Wang Y, et al. Among authors: larsen sd, larsen mj. ACS Chem Neurosci. 2012 Jul 18;3(7):546-56. doi: 10.1021/cn3000235. Epub 2012 Mar 29. ACS Chem Neurosci. 2012. PMID: 22860224 Free PMC article.
Novel inhibitors of bacterial virulence: development of 5,6-dihydrobenzo[h]quinazolin-4(3H)-ones for the inhibition of group A streptococcal streptokinase expression.
Yestrepsky BD, Xu Y, Breen ME, Li X, Rajeswaran WG, Ryu JG, Sorenson RJ, Tsume Y, Wilson MW, Zhang W, Sun D, Sun H, Larsen SD. Yestrepsky BD, et al. Among authors: larsen sd. Bioorg Med Chem. 2013 Apr 1;21(7):1880-97. doi: 10.1016/j.bmc.2013.01.046. Epub 2013 Feb 1. Bioorg Med Chem. 2013. PMID: 23433668 Free PMC article.
The role of HTS in drug discovery at the University of Michigan.
Larsen MJ, Larsen SD, Fribley A, Grembecka J, Homan K, Mapp A, Haak A, Nikolovska-Coleska Z, Stuckey JA, Sun D, Sherman DH. Larsen MJ, et al. Among authors: larsen sd. Comb Chem High Throughput Screen. 2014 Mar;17(3):210-30. doi: 10.2174/1386207317666140109121546. Comb Chem High Throughput Screen. 2014. PMID: 24409957 Free PMC article. Review.
Pharmacokinetic optimitzation of CCG-203971: Novel inhibitors of the Rho/MRTF/SRF transcriptional pathway as potential antifibrotic therapeutics for systemic scleroderma.
Hutchings KM, Lisabeth EM, Rajeswaran W, Wilson MW, Sorenson RJ, Campbell PL, Ruth JH, Amin A, Tsou PS, Leipprandt JR, Olson SR, Wen B, Zhao T, Sun D, Khanna D, Fox DA, Neubig RR, Larsen SD. Hutchings KM, et al. Among authors: larsen sd. Bioorg Med Chem Lett. 2017 Apr 15;27(8):1744-1749. doi: 10.1016/j.bmcl.2017.02.070. Epub 2017 Mar 10. Bioorg Med Chem Lett. 2017. PMID: 28285914 Free PMC article.
104 results