Natural (dihydro)phenanthrene plant compounds are direct activators of AMPK through its allosteric drug and metabolite-binding site.
Sanders MJ, Ratinaud Y, Neopane K, Bonhoure N, Day EA, Ciclet O, Lassueur S, Naranjo Pinta M, Deak M, Brinon B, Christen S, Steinberg GR, Barron D, Sakamoto K.
Sanders MJ, et al. Among authors: barron d.
J Biol Chem. 2022 May;298(5):101852. doi: 10.1016/j.jbc.2022.101852. Epub 2022 Mar 21.
J Biol Chem. 2022.
PMID: 35331736
Free PMC article.