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TNF receptor-associated factor 6 interacts with ALS-linked misfolded superoxide dismutase 1 and promotes aggregation.
Semmler S, Gagné M, Garg P, Pickles SR, Baudouin C, Hamon-Keromen E, Destroismaisons L, Khalfallah Y, Chaineau M, Caron E, Bayne AN, Trempe JF, Cashman NR, Star AT, Haqqani AS, Durcan TM, Meiering EM, Robertson J, Grandvaux N, Plotkin SS, McBride HM, Vande Velde C. Semmler S, et al. Among authors: pickles sr. J Biol Chem. 2020 Mar 20;295(12):3808-3825. doi: 10.1074/jbc.RA119.011215. Epub 2020 Feb 6. J Biol Chem. 2020. PMID: 32029478 Free PMC article.
Misfolded SOD1 and ALS: zeroing in on mitochondria.
Pickles S, Vande Velde C. Pickles S, et al. Amyotroph Lateral Scler. 2012 Jun;13(4):333-40. doi: 10.3109/17482968.2012.648645. Epub 2012 Apr 3. Amyotroph Lateral Scler. 2012. PMID: 22471903 Review.
ALS-linked misfolded SOD1 species have divergent impacts on mitochondria.
Pickles S, Semmler S, Broom HR, Destroismaisons L, Legroux L, Arbour N, Meiering E, Cashman NR, Vande Velde C. Pickles S, et al. Acta Neuropathol Commun. 2016 Apr 27;4(1):43. doi: 10.1186/s40478-016-0313-8. Acta Neuropathol Commun. 2016. PMID: 27121871 Free PMC article.
TDP-43 represses cryptic exon inclusion in the FTD-ALS gene UNC13A.
Ma XR, Prudencio M, Koike Y, Vatsavayai SC, Kim G, Harbinski F, Briner A, Rodriguez CM, Guo C, Akiyama T, Schmidt HB, Cummings BB, Wyatt DW, Kurylo K, Miller G, Mekhoubad S, Sallee N, Mekonnen G, Ganser L, Rubien JD, Jansen-West K, Cook CN, Pickles S, Oskarsson B, Graff-Radford NR, Boeve BF, Knopman DS, Petersen RC, Dickson DW, Shorter J, Myong S, Green EM, Seeley WW, Petrucelli L, Gitler AD. Ma XR, et al. Nature. 2022 Mar;603(7899):124-130. doi: 10.1038/s41586-022-04424-7. Epub 2022 Feb 23. Nature. 2022. PMID: 35197626 Free PMC article.
19 results