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Selective inhibition of Ph-positive ALL cell growth through kinase-dependent and -independent effects by CDK6-specific PROTACs.
De Dominici M, Porazzi P, Xiao Y, Chao A, Tang HY, Kumar G, Fortina P, Spinelli O, Rambaldi A, Peterson LF, Petruk S, Barletta C, Mazo A, Cingolani G, Salvino JM, Calabretta B. De Dominici M, et al. Among authors: calabretta b. Blood. 2020 Apr 30;135(18):1560-1573. doi: 10.1182/blood.2019003604. Blood. 2020. PMID: 32040545 Free PMC article.
Targeting CDK6 and BCL2 Exploits the "MYB Addiction" of Ph+ Acute Lymphoblastic Leukemia.
De Dominici M, Porazzi P, Soliera AR, Mariani SA, Addya S, Fortina P, Peterson LF, Spinelli O, Rambaldi A, Martinelli G, Ferrari A, Iacobucci I, Calabretta B. De Dominici M, et al. Among authors: calabretta b. Cancer Res. 2018 Feb 15;78(4):1097-1109. doi: 10.1158/0008-5472.CAN-17-2644. Epub 2017 Dec 12. Cancer Res. 2018. PMID: 29233926 Free PMC article.
Structure-Based Screen Identifies a Potent Small Molecule Inhibitor of Stat5a/b with Therapeutic Potential for Prostate Cancer and Chronic Myeloid Leukemia.
Liao Z, Gu L, Vergalli J, Mariani SA, De Dominici M, Lokareddy RK, Dagvadorj A, Purushottamachar P, McCue PA, Trabulsi E, Lallas CD, Gupta S, Ellsworth E, Blackmon S, Ertel A, Fortina P, Leiby B, Xia G, Rui H, Hoang DT, Gomella LG, Cingolani G, Njar V, Pattabiraman N, Calabretta B, Nevalainen MT. Liao Z, et al. Among authors: calabretta b. Mol Cancer Ther. 2015 Aug;14(8):1777-93. doi: 10.1158/1535-7163.MCT-14-0883. Epub 2015 May 29. Mol Cancer Ther. 2015. PMID: 26026053 Free PMC article.
Targeting Chemotherapy to Decondensed H3K27me3-Marked Chromatin of AML Cells Enhances Leukemia Suppression.
Porazzi P, Petruk S, Pagliaroli L, De Dominici M, Deming D 2nd, Puccetti MV, Kushinsky S, Kumar G, Minieri V, Barbieri E, Deliard S, Grande A, Trizzino M, Gardini A, Canaani E, Palmisiano N, Porcu P, Ertel A, Fortina P, Eischen CM, Mazo A, Calabretta B. Porazzi P, et al. Among authors: calabretta b. Cancer Res. 2022 Feb 1;82(3):458-471. doi: 10.1158/0008-5472.CAN-21-1297. Epub 2021 Dec 13. Cancer Res. 2022. PMID: 34903608 Free PMC article.
Transcriptional activation of the miR-17-92 cluster is involved in the growth-promoting effects of MYB in human Ph-positive leukemia cells.
Spagnuolo M, Regazzo G, De Dominici M, Sacconi A, Pelosi A, Korita E, Marchesi F, Pisani F, Magenta A, Lulli V, Cordone I, Mengarelli A, Strano S, Blandino G, Rizzo MG, Calabretta B. Spagnuolo M, et al. Among authors: calabretta b. Haematologica. 2019 Jan;104(1):82-92. doi: 10.3324/haematol.2018.191213. Epub 2018 Aug 3. Haematologica. 2019. PMID: 30076175 Free PMC article.
252 results