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ESCO1 and CTCF enable formation of long chromatin loops by protecting cohesinSTAG1 from WAPL.
Wutz G, Ladurner R, St Hilaire BG, Stocsits RR, Nagasaka K, Pignard B, Sanborn A, Tang W, Várnai C, Ivanov MP, Schoenfelder S, van der Lelij P, Huang X, Dürnberger G, Roitinger E, Mechtler K, Davidson IF, Fraser P, Lieberman-Aiden E, Peters JM. Wutz G, et al. Among authors: sanborn a. Elife. 2020 Feb 17;9:e52091. doi: 10.7554/eLife.52091. Elife. 2020. PMID: 32065581 Free PMC article.
Chromatin extrusion explains key features of loop and domain formation in wild-type and engineered genomes.
Sanborn AL, Rao SS, Huang SC, Durand NC, Huntley MH, Jewett AI, Bochkov ID, Chinnappan D, Cutkosky A, Li J, Geeting KP, Gnirke A, Melnikov A, McKenna D, Stamenova EK, Lander ES, Aiden EL. Sanborn AL, et al. Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):E6456-65. doi: 10.1073/pnas.1518552112. Epub 2015 Oct 23. Proc Natl Acad Sci U S A. 2015. PMID: 26499245 Free PMC article.
Cohesin Loss Eliminates All Loop Domains.
Rao SSP, Huang SC, Glenn St Hilaire B, Engreitz JM, Perez EM, Kieffer-Kwon KR, Sanborn AL, Johnstone SE, Bascom GD, Bochkov ID, Huang X, Shamim MS, Shin J, Turner D, Ye Z, Omer AD, Robinson JT, Schlick T, Bernstein BE, Casellas R, Lander ES, Aiden EL. Rao SSP, et al. Cell. 2017 Oct 5;171(2):305-320.e24. doi: 10.1016/j.cell.2017.09.026. Cell. 2017. PMID: 28985562 Free PMC article.
The Energetics and Physiological Impact of Cohesin Extrusion.
Vian L, Pękowska A, Rao SSP, Kieffer-Kwon KR, Jung S, Baranello L, Huang SC, El Khattabi L, Dose M, Pruett N, Sanborn AL, Canela A, Maman Y, Oksanen A, Resch W, Li X, Lee B, Kovalchuk AL, Tang Z, Nelson S, Di Pierro M, Cheng RR, Machol I, St Hilaire BG, Durand NC, Shamim MS, Stamenova EK, Onuchic JN, Ruan Y, Nussenzweig A, Levens D, Aiden EL, Casellas R. Vian L, et al. Among authors: sanborn al. Cell. 2018 May 17;173(5):1165-1178.e20. doi: 10.1016/j.cell.2018.03.072. Epub 2018 Apr 26. Cell. 2018. PMID: 29706548 Free PMC article.
Simple biochemical features underlie transcriptional activation domain diversity and dynamic, fuzzy binding to Mediator.
Sanborn AL, Yeh BT, Feigerle JT, Hao CV, Townshend RJ, Lieberman Aiden E, Dror RO, Kornberg RD. Sanborn AL, et al. Elife. 2021 Apr 27;10:e68068. doi: 10.7554/eLife.68068. Elife. 2021. PMID: 33904398 Free PMC article.
AD-Mediator interaction in vitro was unaffected by a large excess of free activator protein, pointing to a dynamic mechanism of interaction. ...Three-quarters of them bound to a subunit of the Mediator complex called Med15. Sanborn et al. then develope …
AD-Mediator interaction in vitro was unaffected by a large excess of free activator protein, pointing to a dynamic mechanism o …
Deletion of DXZ4 on the human inactive X chromosome alters higher-order genome architecture.
Darrow EM, Huntley MH, Dudchenko O, Stamenova EK, Durand NC, Sun Z, Huang SC, Sanborn AL, Machol I, Shamim M, Seberg AP, Lander ES, Chadwick BP, Aiden EL. Darrow EM, et al. Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):E4504-12. doi: 10.1073/pnas.1609643113. Epub 2016 Jul 18. Proc Natl Acad Sci U S A. 2016. PMID: 27432957 Free PMC article.
The Energetics and Physiological Impact of Cohesin Extrusion.
Vian L, Pękowska A, Rao SSP, Kieffer-Kwon KR, Jung S, Baranello L, Huang SC, El Khattabi L, Dose M, Pruett N, Sanborn AL, Canela A, Maman Y, Oksanen A, Resch W, Li X, Lee B, Kovalchuk AL, Tang Z, Nelson S, Di Pierro M, Cheng RR, Machol I, St Hilaire BG, Durand NC, Shamim MS, Stamenova EK, Onuchic JN, Ruan Y, Nussenzweig A, Levens D, Aiden EL, Casellas R. Vian L, et al. Among authors: sanborn al. Cell. 2018 Sep 20;175(1):292-294. doi: 10.1016/j.cell.2018.09.002. Cell. 2018. PMID: 30241609 Free PMC article. No abstract available.
Structural insights into µ-opioid receptor activation.
Huang W, Manglik A, Venkatakrishnan AJ, Laeremans T, Feinberg EN, Sanborn AL, Kato HE, Livingston KE, Thorsen TS, Kling RC, Granier S, Gmeiner P, Husbands SM, Traynor JR, Weis WI, Steyaert J, Dror RO, Kobilka BK. Huang W, et al. Among authors: sanborn al. Nature. 2015 Aug 20;524(7565):315-21. doi: 10.1038/nature14886. Epub 2015 Aug 5. Nature. 2015. PMID: 26245379 Free PMC article.
126 results