Wen Y - Search Results

1

Validation of a de-immunization strategy for monoclonal antibodies using cynomolgus macaque as a surrogate for human.

Kovalova N, Boyles J, Wen Y, Witcher DR, Brown-Augsburger PL, Wroblewski VJ, Chlewicki LK. Kovalova N, et al. Among authors: wen y. Biopharm Drug Dispos. 2020 Mar;41(3):111-125. doi: 10.1002/bdd.2222. Epub 2020 Mar 10. Biopharm Drug Dispos. 2020. PMID: 32080869

2

Post-hoc assessment of the immunogenicity of three antibodies reveals distinct immune stimulatory mechanisms.

Walsh RE, Lannan M, Wen Y, Wang X, Moreland CA, Willency J, Knierman MD, Spindler L, Liu L, Zeng W, Rocha GV, Obungu V, Lu J, Kaliyaperumal A, Ferrante A, Siegel R, Malherbe LP. Walsh RE, et al. Among authors: wen y. MAbs. 2020 Jan-Dec;12(1):1764829. doi: 10.1080/19420862.2020.1764829. MAbs. 2020. PMID: 32370596 Free PMC article.

3

Investigation of Immune Responses to Oxidation, Deamidation, And Isomerization in Therapeutic Antibodies using Preclinical Immunogenicity Risk Assessment Assays.

Zeunik R, Ryuzoji AF, Peariso A, Wang X, Lannan M, Spindler LJ, Knierman M, Copeland V, Patel C, Wen Y. Zeunik R, et al. Among authors: wen y. J Pharm Sci. 2022 Aug;111(8):2217-2229. doi: 10.1016/j.xphs.2022.05.005. Epub 2022 May 13. J Pharm Sci. 2022. PMID: 35577116

4

Cross-Reactive Polyclonal Antibodies Raised Against GalNAc-Conjugated siRNA Recognize Mostly the GalNAc Moiety.

Ballman KK, Peek VL, Sloan JH, Li J, Konrad RJ, Wen Y. Ballman KK, et al. Among authors: wen y. AAPS J. 2024 Apr 3;26(3):41. doi: 10.1208/s12248-024-00914-w. AAPS J. 2024. PMID: 38570436

5

Development of a FRET-Based Assay for Analysis of mAbs Internalization and Processing by Dendritic Cells in Preclinical Immunogenicity Risk Assessment.

Wen Y, Cahya S, Zeng W, Lin J, Wang X, Liu L, Malherbe L, Siegel R, Ferrante A, Kaliyaperumal A. Wen Y, et al. AAPS J. 2020 Apr 16;22(3):68. doi: 10.1208/s12248-020-00444-1. AAPS J. 2020. PMID: 32300899

6

Comparability study of monocyte derived dendritic cells, primary monocytes, and THP1 cells for innate immune responses.

Wen Y, Wang X, Cahya S, Anderson P, Velasquez C, Torres C, Ferrante A, Kaliyaperumal A. Wen Y, et al. J Immunol Methods. 2021 Nov;498:113147. doi: 10.1016/j.jim.2021.113147. Epub 2021 Sep 9. J Immunol Methods. 2021. PMID: 34508774

7

A competitive ligand binding assay for detection of neutralizing antibodies against an insulin analog.

Peek VL, Lemen DM, Konrad RJ, Wen Y. Peek VL, et al. Among authors: wen y. J Immunol Methods. 2023 Dec;523:113575. doi: 10.1016/j.jim.2023.113575. Epub 2023 Oct 14. J Immunol Methods. 2023. PMID: 37844794

8

The Impact of Product and Process Related Critical Quality Attributes on Immunogenicity and Adverse Immunological Effects of Biotherapeutics.

Wen Y, Jawa V. Wen Y, et al. J Pharm Sci. 2021 Mar;110(3):1025-1041. doi: 10.1016/j.xphs.2020.12.003. Epub 2020 Dec 11. J Pharm Sci. 2021. PMID: 33316242 Review.

9

A sensitive and drug tolerant assay for detecting anti-AAV9 antibodies using affinity capture elution.

Simmons E, Wen Y, Li J, Qian YW, Wong LC, Konrad RJ, Bivi N. Simmons E, et al. Among authors: wen y. J Immunol Methods. 2023 Jan;512:113397. doi: 10.1016/j.jim.2022.113397. Epub 2022 Dec 5. J Immunol Methods. 2023. PMID: 36481208

10

Survey Outcome on Immunogenicity Risk Assessment Tools for Biotherapeutics: an Insight into Consensus on Methods, Application, and Utility in Drug Development.

Gokemeijer J, Wen Y, Jawa V, Mitra-Kaushik S, Chung S, Goggins A, Kumar S, Lamberth K, Liao K, Lill J, Phung Q, Walsh R, Roberts BJ, Swanson M, Singh I, Tourdot S, Kroenke MA, Rup B, Goletz TJ, Gupta S, Malherbe L, Pattijn S. Gokemeijer J, et al. Among authors: wen y. AAPS J. 2023 Jun 2;25(4):55. doi: 10.1208/s12248-023-00820-7. AAPS J. 2023. PMID: 37266912

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