Wroblewski VJ - Search Results

1

Validation of a de-immunization strategy for monoclonal antibodies using cynomolgus macaque as a surrogate for human.

Kovalova N, Boyles J, Wen Y, Witcher DR, Brown-Augsburger PL, Wroblewski VJ, Chlewicki LK. Kovalova N, et al. Among authors: wroblewski vj. Biopharm Drug Dispos. 2020 Mar;41(3):111-125. doi: 10.1002/bdd.2222. Epub 2020 Mar 10. Biopharm Drug Dispos. 2020. PMID: 32080869

2

Humanized IgG1 variants with differential binding properties to the neonatal Fc receptor: relationship to pharmacokinetics in mice and primates.

Datta-Mannan A, Witcher DR, Tang Y, Watkins J, Jiang W, Wroblewski VJ. Datta-Mannan A, et al. Among authors: wroblewski vj. Drug Metab Dispos. 2007 Jan;35(1):86-94. doi: 10.1124/dmd.106.011734. Epub 2006 Oct 18. Drug Metab Dispos. 2007. PMID: 17050651

3

Influence of improved FcRn binding on the subcutaneous bioavailability of monoclonal antibodies in cynomolgus monkeys.

Datta-Mannan A, Witcher DR, Lu J, Wroblewski VJ. Datta-Mannan A, et al. Among authors: wroblewski vj. MAbs. 2012 Mar-Apr;4(2):267-73. doi: 10.4161/mabs.4.2.19364. Epub 2012 Mar 1. MAbs. 2012. PMID: 22377715 Free PMC article.

4

FcRn affinity-pharmacokinetic relationship of five human IgG4 antibodies engineered for improved in vitro FcRn binding properties in cynomolgus monkeys.

Datta-Mannan A, Chow CK, Dickinson C, Driver D, Lu J, Witcher DR, Wroblewski VJ. Datta-Mannan A, et al. Among authors: wroblewski vj. Drug Metab Dispos. 2012 Aug;40(8):1545-55. doi: 10.1124/dmd.112.045864. Epub 2012 May 14. Drug Metab Dispos. 2012. PMID: 22584253

5

Correlation between antidrug antibodies, pre-existing antidrug reactivity, and immunogenetics (MHC class II alleles) in cynomolgus macaque.

Kovalova N, Knierman MD, Brown-Augsburger PL, Wroblewski VJ, Chlewicki LK. Kovalova N, et al. Among authors: wroblewski vj. Immunogenetics. 2019 Nov;71(10):605-615. doi: 10.1007/s00251-019-01136-7. Epub 2019 Nov 27. Immunogenetics. 2019. PMID: 31776588

6

Pharmacokinetics, metabolic stability, and subcutaneous bioavailability of a genetically engineered analog of DcR3, FLINT [DcR3(R218Q)], in cynomolgus monkeys and mice.

Wroblewski VJ, McCloud C, Davis K, Manetta J, Micanovic R, Witcher DR. Wroblewski VJ, et al. Drug Metab Dispos. 2003 Apr;31(4):502-7. doi: 10.1124/dmd.31.4.502. Drug Metab Dispos. 2003. PMID: 12642478

7

Monoclonal antibody clearance. Impact of modulating the interaction of IgG with the neonatal Fc receptor.

Datta-Mannan A, Witcher DR, Tang Y, Watkins J, Wroblewski VJ. Datta-Mannan A, et al. Among authors: wroblewski vj. J Biol Chem. 2007 Jan 19;282(3):1709-17. doi: 10.1074/jbc.M607161200. Epub 2006 Nov 29. J Biol Chem. 2007. PMID: 17135257 Free article.

8

Balancing charge in the complementarity-determining regions of humanized mAbs without affecting pI reduces non-specific binding and improves the pharmacokinetics.

Datta-Mannan A, Thangaraju A, Leung D, Tang Y, Witcher DR, Lu J, Wroblewski VJ. Datta-Mannan A, et al. Among authors: wroblewski vj. MAbs. 2015;7(3):483-93. doi: 10.1080/19420862.2015.1016696. MAbs. 2015. PMID: 25695748 Free PMC article.

9

The interplay of non-specific binding, target-mediated clearance and FcRn interactions on the pharmacokinetics of humanized antibodies.

Datta-Mannan A, Lu J, Witcher DR, Leung D, Tang Y, Wroblewski VJ. Datta-Mannan A, et al. Among authors: wroblewski vj. MAbs. 2015;7(6):1084-93. doi: 10.1080/19420862.2015.1075109. Epub 2015 Sep 4. MAbs. 2015. PMID: 26337808 Free PMC article.

10

A dual-monoclonal sandwich ELISA specific for hepcidin-25.

Butterfield AM, Luan P, Witcher DR, Manetta J, Murphy AT, Wroblewski VJ, Konrad RJ. Butterfield AM, et al. Among authors: wroblewski vj. Clin Chem. 2010 Nov;56(11):1725-32. doi: 10.1373/clinchem.2010.151522. Epub 2010 Sep 16. Clin Chem. 2010. PMID: 20847326

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