LeVine MV - Search Results

1

X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release.

Gotfryd K, Boesen T, Mortensen JS, Khelashvili G, Quick M, Terry DS, Missel JW, LeVine MV, Gourdon P, Blanchard SC, Javitch JA, Weinstein H, Loland CJ, Nissen P, Gether U. Gotfryd K, et al. Among authors: levine mv. Nat Commun. 2020 Feb 21;11(1):1005. doi: 10.1038/s41467-020-14735-w. Nat Commun. 2020. PMID: 32081981 Free PMC article.

2

The membrane protein LeuT in micellar systems: aggregation dynamics and detergent binding to the S2 site.

Khelashvili G, LeVine MV, Shi L, Quick M, Javitch JA, Weinstein H. Khelashvili G, et al. Among authors: levine mv. J Am Chem Soc. 2013 Sep 25;135(38):14266-75. doi: 10.1021/ja405984v. Epub 2013 Sep 16. J Am Chem Soc. 2013. PMID: 23980525 Free PMC article.

3

A partially-open inward-facing intermediate conformation of LeuT is associated with Na⁺ release and substrate transport.

Terry DS, Kolster RA, Quick M, LeVine MV, Khelashvili G, Zhou Z, Weinstein H, Javitch JA, Blanchard SC. Terry DS, et al. Among authors: levine mv. Nat Commun. 2018 Jan 15;9(1):230. doi: 10.1038/s41467-017-02202-y. Nat Commun. 2018. PMID: 29335402 Free PMC article.

4

The allosteric mechanism of substrate-specific transport in SLC6 is mediated by a volumetric sensor.

LeVine MV, Terry DS, Khelashvili G, Siegel ZS, Quick M, Javitch JA, Blanchard SC, Weinstein H. LeVine MV, et al. Proc Natl Acad Sci U S A. 2019 Aug 6;116(32):15947-15956. doi: 10.1073/pnas.1903020116. Epub 2019 Jul 19. Proc Natl Acad Sci U S A. 2019. PMID: 31324743 Free PMC article.

5

NbIT--a new information theory-based analysis of allosteric mechanisms reveals residues that underlie function in the leucine transporter LeuT.

LeVine MV, Weinstein H. LeVine MV, et al. PLoS Comput Biol. 2014 May 1;10(5):e1003603. doi: 10.1371/journal.pcbi.1003603. eCollection 2014 May. PLoS Comput Biol. 2014. PMID: 24785005 Free PMC article.

6

Role of Annular Lipids in the Functional Properties of Leucine Transporter LeuT Proteomicelles.

LeVine MV, Khelashvili G, Shi L, Quick M, Javitch JA, Weinstein H. LeVine MV, et al. Biochemistry. 2016 Feb 16;55(6):850-9. doi: 10.1021/acs.biochem.5b01268. Epub 2016 Feb 5. Biochemistry. 2016. PMID: 26811944 Free PMC article.

7

Thermodynamic Coupling Function Analysis of Allosteric Mechanisms in the Human Dopamine Transporter.

LeVine MV, Cuendet MA, Razavi AM, Khelashvili G, Weinstein H. LeVine MV, et al. Biophys J. 2018 Jan 9;114(1):10-14. doi: 10.1016/j.bpj.2017.10.030. Epub 2017 Nov 15. Biophys J. 2018. PMID: 29153319 Free PMC article.

8

The allosteric mechanism leading to an open-groove lipid conductive state of the TMEM16F scramblase.

Khelashvili G, Kots E, Cheng X, Levine MV, Weinstein H. Khelashvili G, et al. Among authors: levine mv. Commun Biol. 2022 Sep 19;5(1):990. doi: 10.1038/s42003-022-03930-8. Commun Biol. 2022. PMID: 36123525 Free PMC article.

9

A functional selectivity mechanism at the serotonin-2A GPCR involves ligand-dependent conformations of intracellular loop 2.

Perez-Aguilar JM, Shan J, LeVine MV, Khelashvili G, Weinstein H. Perez-Aguilar JM, et al. Among authors: levine mv. J Am Chem Soc. 2014 Nov 12;136(45):16044-54. doi: 10.1021/ja508394x. Epub 2014 Oct 31. J Am Chem Soc. 2014. PMID: 25314362 Free PMC article.

10

Spontaneous inward opening of the dopamine transporter is triggered by PIP2-regulated dynamics of the N-terminus.

Khelashvili G, Stanley N, Sahai MA, Medina J, LeVine MV, Shi L, De Fabritiis G, Weinstein H. Khelashvili G, et al. Among authors: levine mv. ACS Chem Neurosci. 2015 Nov 18;6(11):1825-37. doi: 10.1021/acschemneuro.5b00179. Epub 2015 Aug 17. ACS Chem Neurosci. 2015. PMID: 26255829 Free PMC article.

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