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Analgesic treatment with buprenorphine should be adapted to the mouse strain.
Rudeck J, Vogl S, Heinl C, Steinfath M, Fritzwanker S, Kliewer A, Schulz S, Schönfelder G, Bert B. Rudeck J, et al. Among authors: fritzwanker s. Pharmacol Biochem Behav. 2020 Apr;191:172877. doi: 10.1016/j.pbb.2020.172877. Epub 2020 Feb 20. Pharmacol Biochem Behav. 2020. PMID: 32088361 Free article.
Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists.
Gillis A, Gondin AB, Kliewer A, Sanchez J, Lim HD, Alamein C, Manandhar P, Santiago M, Fritzwanker S, Schmiedel F, Katte TA, Reekie T, Grimsey NL, Kassiou M, Kellam B, Krasel C, Halls ML, Connor M, Lane JR, Schulz S, Christie MJ, Canals M. Gillis A, et al. Among authors: fritzwanker s. Sci Signal. 2020 Mar 31;13(625):eaaz3140. doi: 10.1126/scisignal.aaz3140. Sci Signal. 2020. PMID: 32234959
A bead-based GPCR phosphorylation immunoassay for high-throughput ligand profiling and GRK inhibitor screening.
Kaufmann J, Blum NK, Nagel F, Schuler A, Drube J, Degenhart C, Engel J, Eickhoff JE, Dasgupta P, Fritzwanker S, Guastadisegni M, Schulte C, Miess-Tanneberg E, Maric HM, Spetea M, Kliewer A, Baumann M, Klebl B, Reinscheid RK, Hoffmann C, Schulz S. Kaufmann J, et al. Among authors: fritzwanker s. Commun Biol. 2022 Nov 9;5(1):1206. doi: 10.1038/s42003-022-04135-9. Commun Biol. 2022. PMID: 36352263 Free PMC article.
Key phosphorylation sites for robust β-arrestin2 binding at the MOR revisited.
Underwood O, Fritzwanker S, Glenn J, Blum NK, Batista-Gondin A, Drube J, Hoffmann C, Briddon SJ, Schulz S, Canals M. Underwood O, et al. Among authors: fritzwanker s. Commun Biol. 2024 Aug 2;7(1):933. doi: 10.1038/s42003-024-06571-1. Commun Biol. 2024. PMID: 39095612 Free PMC article.