Gan L - Search Results

1

Regulation of Tau Homeostasis and Toxicity by Acetylation.

Tracy T, Claiborn KC, Gan L. Tracy T, et al. Among authors: gan l. Adv Exp Med Biol. 2019;1184:47-55. doi: 10.1007/978-981-32-9358-8_4. Adv Exp Med Biol. 2019. PMID: 32096027 Review.

2

Acetylation of tau inhibits its degradation and contributes to tauopathy.

Min SW, Cho SH, Zhou Y, Schroeder S, Haroutunian V, Seeley WW, Huang EJ, Shen Y, Masliah E, Mukherjee C, Meyers D, Cole PA, Ott M, Gan L. Min SW, et al. Among authors: gan l. Neuron. 2010 Sep 23;67(6):953-66. doi: 10.1016/j.neuron.2010.08.044. Neuron. 2010. PMID: 20869593 Free PMC article.

3

Argyrophilic grain disease differs from other tauopathies by lacking tau acetylation.

Grinberg LT, Wang X, Wang C, Sohn PD, Theofilas P, Sidhu M, Arevalo JB, Heinsen H, Huang EJ, Rosen H, Miller BL, Gan L, Seeley WW. Grinberg LT, et al. Among authors: gan l. Acta Neuropathol. 2013 Apr;125(4):581-93. doi: 10.1007/s00401-013-1080-2. Epub 2013 Jan 31. Acta Neuropathol. 2013. PMID: 23371364 Free PMC article.

4

Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits.

Min SW, Chen X, Tracy TE, Li Y, Zhou Y, Wang C, Shirakawa K, Minami SS, Defensor E, Mok SA, Sohn PD, Schilling B, Cong X, Ellerby L, Gibson BW, Johnson J, Krogan N, Shamloo M, Gestwicki J, Masliah E, Verdin E, Gan L. Min SW, et al. Among authors: gan l. Nat Med. 2015 Oct;21(10):1154-62. doi: 10.1038/nm.3951. Epub 2015 Sep 21. Nat Med. 2015. PMID: 26390242 Free PMC article.

5

Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss.

Tracy TE, Sohn PD, Minami SS, Wang C, Min SW, Li Y, Zhou Y, Le D, Lo I, Ponnusamy R, Cong X, Schilling B, Ellerby LM, Huganir RL, Gan L. Tracy TE, et al. Among authors: gan l. Neuron. 2016 Apr 20;90(2):245-60. doi: 10.1016/j.neuron.2016.03.005. Epub 2016 Mar 31. Neuron. 2016. PMID: 27041503 Free PMC article.

6

Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment.

Sohn PD, Tracy TE, Son HI, Zhou Y, Leite RE, Miller BL, Seeley WW, Grinberg LT, Gan L. Sohn PD, et al. Among authors: gan l. Mol Neurodegener. 2016 Jun 29;11(1):47. doi: 10.1186/s13024-016-0109-0. Mol Neurodegener. 2016. PMID: 27356871 Free PMC article.

7

Acetylated tau in Alzheimer's disease: An instigator of synaptic dysfunction underlying memory loss: Increased levels of acetylated tau blocks the postsynaptic signaling required for plasticity and promotes memory deficits associated with tauopathy.

Tracy TE, Gan L. Tracy TE, et al. Among authors: gan l. Bioessays. 2017 Apr;39(4):10.1002/bies.201600224. doi: 10.1002/bies.201600224. Epub 2017 Jan 13. Bioessays. 2017. PMID: 28083916 Free PMC article. Review.

8

Scalable Production of iPSC-Derived Human Neurons to Identify Tau-Lowering Compounds by High-Content Screening.

Wang C, Ward ME, Chen R, Liu K, Tracy TE, Chen X, Xie M, Sohn PD, Ludwig C, Meyer-Franke A, Karch CM, Ding S, Gan L. Wang C, et al. Among authors: gan l. Stem Cell Reports. 2017 Oct 10;9(4):1221-1233. doi: 10.1016/j.stemcr.2017.08.019. Epub 2017 Sep 28. Stem Cell Reports. 2017. PMID: 28966121 Free PMC article.

9

SIRT1 Deacetylates Tau and Reduces Pathogenic Tau Spread in a Mouse Model of Tauopathy.

Min SW, Sohn PD, Li Y, Devidze N, Johnson JR, Krogan NJ, Masliah E, Mok SA, Gestwicki JE, Gan L. Min SW, et al. Among authors: gan l. J Neurosci. 2018 Apr 11;38(15):3680-3688. doi: 10.1523/JNEUROSCI.2369-17.2018. Epub 2018 Mar 14. J Neurosci. 2018. PMID: 29540553 Free PMC article.

10

Nav1.1-Overexpressing Interneuron Transplants Restore Brain Rhythms and Cognition in a Mouse Model of Alzheimer's Disease.

Martinez-Losa M, Tracy TE, Ma K, Verret L, Clemente-Perez A, Khan AS, Cobos I, Ho K, Gan L, Mucke L, Alvarez-Dolado M, Palop JJ. Martinez-Losa M, et al. Among authors: gan l. Neuron. 2018 Apr 4;98(1):75-89.e5. doi: 10.1016/j.neuron.2018.02.029. Epub 2018 Mar 15. Neuron. 2018. PMID: 29551491 Free PMC article.

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