Helman LJ - Search Results

1

CDK9 Blockade Exploits Context-dependent Transcriptional Changes to Improve Activity and Limit Toxicity of Mithramycin for Ewing Sarcoma.

Flores G, Everett JH, Boguslawski EA, Oswald BM, Madaj ZB, Beddows I, Dikalov S, Adams M, Klumpp-Thomas CA, Kitchen-Goosen SM, Martin SE, Caplen NJ, Helman LJ, Grohar PJ. Flores G, et al. Among authors: helman lj. Mol Cancer Ther. 2020 May;19(5):1183-1196. doi: 10.1158/1535-7163.MCT-19-0775. Epub 2020 Mar 3. Mol Cancer Ther. 2020. PMID: 32127464 Free PMC article.

2

Insulin-like growth factor type 1 (IGF-1) and IGF binding protein-3 in patients with Ewing sarcoma family of tumors.

Toretsky JA, Steinberg SM, Thakar M, Counts D, Pironis B, Parente C, Eskenazi A, Helman L, Wexler LH. Toretsky JA, et al. Cancer. 2001 Dec 1;92(11):2941-7. doi: 10.1002/1097-0142(20011201)92:11<2941::aid-cncr10072>3.0.co;2-c. Cancer. 2001. PMID: 11753970

3

Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism.

Wan X, Harkavy B, Shen N, Grohar P, Helman LJ. Wan X, et al. Among authors: helman lj. Oncogene. 2007 Mar 22;26(13):1932-40. doi: 10.1038/sj.onc.1209990. Epub 2006 Sep 25. Oncogene. 2007. PMID: 17001314

4

Addiction to elevated insulin-like growth factor I receptor and initial modulation of the AKT pathway define the responsiveness of rhabdomyosarcoma to the targeting antibody.

Cao L, Yu Y, Darko I, Currier D, Mayeenuddin LH, Wan X, Khanna C, Helman LJ. Cao L, et al. Among authors: helman lj. Cancer Res. 2008 Oct 1;68(19):8039-48. doi: 10.1158/0008-5472.CAN-08-1712. Cancer Res. 2008. PMID: 18829562 Free PMC article.

5

Ecteinascidin 743 interferes with the activity of EWS-FLI1 in Ewing sarcoma cells.

Grohar PJ, Griffin LB, Yeung C, Chen QR, Pommier Y, Khanna C, Khan J, Helman LJ. Grohar PJ, et al. Among authors: helman lj. Neoplasia. 2011 Feb;13(2):145-53. doi: 10.1593/neo.101202. Neoplasia. 2011. PMID: 21403840 Free PMC article.

6

Identification of an inhibitor of the EWS-FLI1 oncogenic transcription factor by high-throughput screening.

Grohar PJ, Woldemichael GM, Griffin LB, Mendoza A, Chen QR, Yeung C, Currier DG, Davis S, Khanna C, Khan J, McMahon JB, Helman LJ. Grohar PJ, et al. Among authors: helman lj. J Natl Cancer Inst. 2011 Jun 22;103(12):962-78. doi: 10.1093/jnci/djr156. Epub 2011 Jun 8. J Natl Cancer Inst. 2011. PMID: 21653923 Free PMC article.

7

Prospects and challenges for the development of new therapies for Ewing sarcoma.

Grohar PJ, Helman LJ. Grohar PJ, et al. Among authors: helman lj. Pharmacol Ther. 2013 Feb;137(2):216-24. doi: 10.1016/j.pharmthera.2012.10.004. Epub 2012 Oct 18. Pharmacol Ther. 2013. PMID: 23085431 Free PMC article. Review.

8

Loss-of-function screen in rhabdomyosarcoma identifies CRKL-YES as a critical signal for tumor growth.

Yeung CL, Ngo VN, Grohar PJ, Arnaldez FI, Asante A, Wan X, Khan J, Hewitt SM, Khanna C, Staudt LM, Helman LJ. Yeung CL, et al. Among authors: helman lj. Oncogene. 2013 Nov 21;32(47):5429-38. doi: 10.1038/onc.2012.590. Epub 2013 Jan 14. Oncogene. 2013. PMID: 23318429 Free PMC article.

9

Dual targeting of EWS-FLI1 activity and the associated DNA damage response with trabectedin and SN38 synergistically inhibits Ewing sarcoma cell growth.

Grohar PJ, Segars LE, Yeung C, Pommier Y, D'Incalci M, Mendoza A, Helman LJ. Grohar PJ, et al. Among authors: helman lj. Clin Cancer Res. 2014 Mar 1;20(5):1190-203. doi: 10.1158/1078-0432.CCR-13-0901. Epub 2013 Nov 25. Clin Cancer Res. 2014. PMID: 24277455 Free PMC article.

10

New strategies in ewing sarcoma: lost in translation?

Arnaldez FI, Helman LJ. Arnaldez FI, et al. Among authors: helman lj. Clin Cancer Res. 2014 Jun 15;20(12):3050-6. doi: 10.1158/1078-0432.CCR-13-0633. Epub 2014 Apr 22. Clin Cancer Res. 2014. PMID: 24756371 Free PMC article.

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